BINDING POLYPEPTIDES WITH OPTIMIZED SCAFFOLDS

BINDING POLYPEPTIDES WITH OPTIMIZED SCAFFOLDS

The invention provides variant heavy chain variable domains (VH) with increased folding stability. Libraries comprising a plurality of these polypeptides are also provided. In addition, compositions and methods of generating and using these polypeptides and libraries are provided.

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Bibliographische Detailangaben
Hauptverfasser: SIDHU SACHDEV S, BARTHELEMY PIERRE A
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The invention provides variant heavy chain variable domains (VH) with increased folding stability. Libraries comprising a plurality of these polypeptides are also provided. In addition, compositions and methods of generating and using these polypeptides and libraries are provided.