COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF

COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF

The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxyl)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxyl)phenyl)pyridin-2-yl)-N-benzylacetamide and it...

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Hauptverfasser: PALMER GRANT J, PATRA DEBASIS, ISBESTER PAUL K, SALSBURY JONATHON, HANGAUER, JR. DAVID G, CODY JEREMY A
Format: Patent
Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator PALMER GRANT J
PATRA DEBASIS
ISBESTER PAUL K
SALSBURY JONATHON
HANGAUER, JR. DAVID G
CODY JEREMY A
description The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxyl)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxyl)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxyl)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title COMPOSITIONS FOR MODULATING A KINASE CASCADE AND METHODS OF USE THEREOF
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