RORGamma Modulators

Described are RORy modulators of the formula (I), and N-oxides thereof, and pharmaceutically acceptable salts thereof, and solvates and hydrates thereof, wherein R1, R2, R3, R4, R5, R6, Ra, x, y, L, G, Z, the bond denoted by "q", the ring system denoted by "A" and the ring system...

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Hauptverfasser:	DHAR T.G. MURALII, JEONG JOON WON, KOLTUN ELENA S, BANNEN LYNN CANNE, XU WEI, WANG YONG, KIM BYUNG GYU, MA SUNGHOON
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
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creator	DHAR T.G. MURALII JEONG JOON WON KOLTUN ELENA S BANNEN LYNN CANNE XU WEI WANG YONG KIM BYUNG GYU MA SUNGHOON
description	Described are RORy modulators of the formula (I), and N-oxides thereof, and pharmaceutically acceptable salts thereof, and solvates and hydrates thereof, wherein R1, R2, R3, R4, R5, R6, Ra, x, y, L, G, Z, the bond denoted by "q", the ring system denoted by "A" and the ring system denoted by "B" are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORy activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORy activity, for example, autoimmune and/or inflammatory disorders.
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MURALII</au><au>JEONG JOON WON</au><au>KOLTUN ELENA S</au><au>BANNEN LYNN CANNE</au><au>XU WEI</au><au>WANG YONG</au><au>KIM BYUNG GYU</au><au>MA SUNGHOON</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>RORGamma Modulators</title><date>2015-09-24</date><risdate>2015</risdate><abstract>Described are RORy modulators of the formula (I), and N-oxides thereof, and pharmaceutically acceptable salts thereof, and solvates and hydrates thereof, wherein R1, R2, R3, R4, R5, R6, Ra, x, y, L, G, Z, the bond denoted by "q", the ring system denoted by "A" and the ring system denoted by "B" are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORy activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORy activity, for example, autoimmune and/or inflammatory disorders.</abstract><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY
title	RORGamma Modulators
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