PYRAZOLYL-UREAS AS KINASE INHIBITORS
There are provided compounds of formula I, wherein R, R1, Ra, Rb, Q, X and Y have meanings given in the description, which compounds have antiinflammatory activity (e.g., through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and memb...
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| creator | CARIOU CLAIRE ANNE MARIE FYFE MATTHEW COLIN THOR HAMZA DANIEL WATSON HAYLEY TEGAN ANGELA FORDYCE EUAN ALEXANDER FRASER THOM STEPHEN MALCOLM MURRAY PETER JOHN CHARRON CATHERINE ELISABETH ITO KAZUHIRO ONIONS STUART THOMAS WILLIAMS JONATHAN GARETH KING-UNDERWOOD JOHN |
| description | There are provided compounds of formula I, wherein R, R1, Ra, Rb, Q, X and Y have meanings given in the description, which compounds have antiinflammatory activity (e.g., through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines. |
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FYFE MATTHEW COLIN THOR ; HAMZA DANIEL ; WATSON HAYLEY TEGAN ANGELA ; FORDYCE EUAN ALEXANDER FRASER ; THOM STEPHEN MALCOLM ; MURRAY PETER JOHN ; CHARRON CATHERINE ELISABETH ; ITO KAZUHIRO ; ONIONS STUART THOMAS ; WILLIAMS JONATHAN GARETH ; KING-UNDERWOOD JOHN</creatorcontrib><description>There are provided compounds of formula I, wherein R, R1, Ra, Rb, Q, X and Y have meanings given in the description, which compounds have antiinflammatory activity (e.g., through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150806&DB=EPODOC&CC=US&NR=2015218137A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150806&DB=EPODOC&CC=US&NR=2015218137A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CARIOU CLAIRE ANNE MARIE</creatorcontrib><creatorcontrib>FYFE MATTHEW COLIN THOR</creatorcontrib><creatorcontrib>HAMZA DANIEL</creatorcontrib><creatorcontrib>WATSON HAYLEY TEGAN ANGELA</creatorcontrib><creatorcontrib>FORDYCE EUAN ALEXANDER FRASER</creatorcontrib><creatorcontrib>THOM STEPHEN MALCOLM</creatorcontrib><creatorcontrib>MURRAY PETER JOHN</creatorcontrib><creatorcontrib>CHARRON CATHERINE ELISABETH</creatorcontrib><creatorcontrib>ITO KAZUHIRO</creatorcontrib><creatorcontrib>ONIONS STUART THOMAS</creatorcontrib><creatorcontrib>WILLIAMS JONATHAN GARETH</creatorcontrib><creatorcontrib>KING-UNDERWOOD JOHN</creatorcontrib><title>PYRAZOLYL-UREAS AS KINASE INHIBITORS</title><description>There are provided compounds of formula I, wherein R, R1, Ra, Rb, Q, X and Y have meanings given in the description, which compounds have antiinflammatory activity (e.g., through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | PYRAZOLYL-UREAS AS KINASE INHIBITORS |
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