PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE

PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE

Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are deli...

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Hauptverfasser: VERA MATTHEW DOUGLAS, VELVADAPU VENKATA NAGA, PELLETIER JEFFREY CLAUDE, SMITH GARRY ROBERT, WROBEL JAY EDWARD, MCDONNELL MARK, CHEN SUZIE, BLASS BENJAMIN ERIC, REITZ ALLEN B
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator VERA MATTHEW DOUGLAS
VELVADAPU VENKATA NAGA
PELLETIER JEFFREY CLAUDE
SMITH GARRY ROBERT
WROBEL JAY EDWARD
MCDONNELL MARK
CHEN SUZIE
BLASS BENJAMIN ERIC
REITZ ALLEN B
description Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title PRODRUGS OF RILUZOLE AND THEIR METHOD OF USE
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