FAST-DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS

FAST-DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS

The present invention relates to 4-aryl-6-piperazin-1-yl-3-substituted-pyridazines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medici...

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Hauptverfasser: BARTOLOMÉ-NEBREDA JOSÉ MANUEL, VAN GOOL MICHIEL LUC MARIA, MACDONALD GREGOR JAMES, LANGLOIS XAVIER JEAN MICHEL
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator BARTOLOMÉ-NEBREDA JOSÉ MANUEL
VAN GOOL MICHIEL LUC MARIA
MACDONALD GREGOR JAMES
LANGLOIS XAVIER JEAN MICHEL
description The present invention relates to 4-aryl-6-piperazin-1-yl-3-substituted-pyridazines that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title FAST-DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS
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