THERAPEUTIC ANTIBODIES BINDING IL 12RBETA1

THERAPEUTIC ANTIBODIES BINDING IL 12RBETA1

The present invention relates to antibodies that specifically bind to IL12R 1, the non-signal transducing chain of the heterodimeric IL12 receptor (together with IL12R 2 chain) as well as IL23 receptor (together with IL23Rα chain). The invention more specifically relates to specific antibodies that...

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Hauptverfasser: DELLA DUCATA DANIELA, CARBALLIDO HERRERA JOSE M, BARDROFF MICHAEL OTTO, HEUSSER CHRISTOPH, JAEGER UTE, SCHWAERZLER CHRISTOPH
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CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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creator DELLA DUCATA DANIELA
CARBALLIDO HERRERA JOSE M
BARDROFF MICHAEL OTTO
HEUSSER CHRISTOPH
JAEGER UTE
SCHWAERZLER CHRISTOPH
description The present invention relates to antibodies that specifically bind to IL12R 1, the non-signal transducing chain of the heterodimeric IL12 receptor (together with IL12R 2 chain) as well as IL23 receptor (together with IL23Rα chain). The invention more specifically relates to specific antibodies that are IL12 and IL23 receptor antagonists capable of inhibiting IL12/IL18 induced IFNy production of T cells and compositions and methods of use for said antibodies to treat pathological disorders that can be treated by inhibiting IFNy production, such as rheumatoid arthritis, psoriasis or inflammatory bowel diseases or other autoimmune and inflammatory disorders.
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subjects CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
title THERAPEUTIC ANTIBODIES BINDING IL 12RBETA1
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