NOVEL FAB FRAGMENT LIBRARIES AND METHODS FOR THEIR USE

The present invention provides Fab libraries and methods for using the Fab libraries to obtain antibodies against a target. The Fab library of the invention contains at least 109 different Fabs, and in some embodiments, at least 1010 different Fabs. The Fab libraries of the invention are used to iso...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser:	HOOGENBOOM HENDRICUS RENERUS JACOBUS MATTHEUS
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY COMBINATORIAL CHEMISTRY LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES METALLURGY ORGANIC CHEMISTRY PEPTIDES
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	The present invention provides Fab libraries and methods for using the Fab libraries to obtain antibodies against a target. The Fab library of the invention contains at least 109 different Fabs, and in some embodiments, at least 1010 different Fabs. The Fab libraries of the invention are used to isolate polyclonal or monoclonal Fabs that bind with high specificity to targets.