IP-10 ANTIBODY DOSAGE ESCALATION REGIMENS

IP-10 ANTIBODY DOSAGE ESCALATION REGIMENS

In certain embodiments, the present invention provides a method of treating an IP-10-related disease in a subject, comprising: (a) administering to the subject a predetermined dosage of an anti-IP-10 antibody; (b) detecting the level of the anti-IP-10 antibody in a sample of the subject; and (c) if...

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Hauptverfasser: CHEN HAIBIN, TRIGONA WENDY L, ZHANG YAN, STOUFFER BRUCE, SHEN JINSHAN, XU LI-AN, HUANG HAICHUN, LUO ALLISON Y, TAO XIAOLU, BROCKUS CATHERINE
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INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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creator CHEN HAIBIN
TRIGONA WENDY L
ZHANG YAN
STOUFFER BRUCE
SHEN JINSHAN
XU LI-AN
HUANG HAICHUN
LUO ALLISON Y
TAO XIAOLU
BROCKUS CATHERINE
description In certain embodiments, the present invention provides a method of treating an IP-10-related disease in a subject, comprising: (a) administering to the subject a predetermined dosage of an anti-IP-10 antibody; (b) detecting the level of the anti-IP-10 antibody in a sample of the subject; and (c) if the level of the anti-IP-10 antibody from step (b) is below a threshold exposure level, increasing the dosage of the anti-IP-10 antibody in the subject such that the IP-10 related disease in the subject is treated. In certain embodiments, the present invention provides an isolated monoclonal anti-idiotypic antibody, or an antigen binding portion thereof, which binds to the anti-IP-10 antibody MDX-1100.
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subjects INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
title IP-10 ANTIBODY DOSAGE ESCALATION REGIMENS
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