PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION

PROCESS FOR PREPARATION OF DRONEDARONE BY N-BUTYLATION

The invention relates to a novel process for preparation of dronedarone (I) and pharmaceutically acceptable salts thereof where the compound of formula (II) or salt thereof is reacted with a compound of formula L-(CH2)3-CH3 (III), where L is a leaving group, and isolating the obtained product and, i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DOMBRÁDY ZSOLT, PÁRKÁNYI ZSOLT, FRIESZ ANTAL
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to a novel process for preparation of dronedarone (I) and pharmaceutically acceptable salts thereof where the compound of formula (II) or salt thereof is reacted with a compound of formula L-(CH2)3-CH3 (III), where L is a leaving group, and isolating the obtained product and, if desired, converting it into a pharmaceutically acceptable salt thereof. The invention also relates to some novel intermediary compounds and the preparation thereof.