Multimeric VLA-4 Antagonists Comprising Polymers Moieties

Disclosed are conjugates which bind VLA-4. Certain of these conjugates also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such conjugates are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's...

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Hauptverfasser: PLEISS MICHAEL A, YEDNOCK THEODORE, KONRADI ANDREI W, SEMKO CHRISTOPHER M, SMITH JENIFER L
Format: Patent
Sprache:eng
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