PREPARATION OF CRYSTALLINE BAZEDOXIFENE AND ITS SALTS

PREPARATION OF CRYSTALLINE BAZEDOXIFENE AND ITS SALTS

Aspects of the present disclosure include crystalline bazedoxifene free base, crystalline bazedoxifene acetate Form D, and processes for their preparation. The drug compound having the adopted name "bazedoxifene acetate" has a chemical name 1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyph...

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Hauptverfasser: SUBBAREDDY PEDDIREDDY, RAGHUNATH VAGWALA, RAMAKRISHNAN SRIVIDYA, KANWAR LALITA, BANDICHHOR RAKESHWAR, BOGE RAJESHAM, LEKKALA AMARNATH REDDY, KANNIAH SUNDRA LAKSHMI, KUMAR RAMYA, MYLAVARAPU RAVI KUMAR
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:Aspects of the present disclosure include crystalline bazedoxifene free base, crystalline bazedoxifene acetate Form D, and processes for their preparation. The drug compound having the adopted name "bazedoxifene acetate" has a chemical name 1-[4-(2-azepan-1-yl-ethoxy)benzyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol acetic acid, and has the chemical structure shown below as Formula I.