Therapeutically Active Alpha-MSH Analogues

The invention describes peptide analogues of alpha-melanocyte-stimulating hormone (alpha-MSH), which posses an increased efficacy compared to the native alpha-MSH peptide. The alpha-MSH analogues exhibit increased anti-inflammatory effects and increased capability to prevent ischemic conditions comp...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	JONASSEN THOMAS E.N, LARSEN BJARNE DUE, NIELSEN SOREN, FROKIAER JORGEN
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES
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Beschreibung
Zusammenfassung:	The invention describes peptide analogues of alpha-melanocyte-stimulating hormone (alpha-MSH), which posses an increased efficacy compared to the native alpha-MSH peptide. The alpha-MSH analogues exhibit increased anti-inflammatory effects and increased capability to prevent ischemic conditions compared to alpha-MSH. The invention further discloses use of the peptides for the manufacture of pharmaceutical compositions for the treatment or prophylaxis of a condition in the tissue of one or more organs of a mammal, and moreover pharmaceutical compositions.