Fused Imidazo [3,2 - D] Pyrazines as P13 Kinase Inhibitors

There is provided compounds of formula (I), wherein A1, A2, A3, A4, n, the dotted lines, B1, B1a, B2, B2a, B3, B3a, B4, B4a, R2 and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of dis...

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Hauptverfasser:	VARELA BUSTO CARMEN, RODRIGUEZ ARISTEGUI SONSOLES, GONZALES CANTALAPIEDRA ESTHER, PASTOR FERNANDEZ JOAQUIN, MARTINEZ GONZALEZ SONIA, ALVAREZ ESCOBAR ROSA MARIA, HERNANDEZ HIGUERAS ANA ISABEL
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Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	VARELA BUSTO CARMEN RODRIGUEZ ARISTEGUI SONSOLES GONZALES CANTALAPIEDRA ESTHER PASTOR FERNANDEZ JOAQUIN MARTINEZ GONZALEZ SONIA ALVAREZ ESCOBAR ROSA MARIA HERNANDEZ HIGUERAS ANA ISABEL
description	There is provided compounds of formula (I), wherein A1, A2, A3, A4, n, the dotted lines, B1, B1a, B2, B2a, B3, B3a, B4, B4a, R2 and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein kinase (e.g. a PI3-K and/or mTOR) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease.
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	Fused Imidazo [3,2 - D] Pyrazines as P13 Kinase Inhibitors
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