CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS

The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercho...

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Bibliographische Detailangaben
Hauptverfasser: HECKER SCOTT, GOKA ELIZABETH, BIYANI KALPESH, BERGBREITER DAVID, CONNOR ERIC, LEES INEZ, ZHANG HONGMIN, KOPPING JORDAN, MU YONGQI, COPE MICHAEL JAMES, SALAYMEH FALEH, QUAKER GRACE, SHAO JUN, MANSKY PAUL, LEE ANGELA, MADSEN DEIDRE
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.