COMPOUND MODIFIED BY A PHOSPHORAMIDATE AND/OR PHOSPHONAMIDE GROUP AND USE THEREOF

A modified compound that has at least one further functional group, in particular a bio- or macromolecule, comprising at least one x-fold (x 1) chemoselectively incorporated phosphoramidate group of general formula (I), NPO(OR1) (OR1′), and/or at least one x-fold (x 1) chemoselectively incorporated...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	VALLEE ROBERT, DEL SIGNORE GIUSEPPE, SERWA REMIGIUSZ, WILKENING INA, HACKENBERGER CHRISTIAN
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY COMPOSITIONS BASED THEREON MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MANUFACTURE OR TREATMENT OF NANOSTRUCTURES MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES METALLURGY NANOTECHNOLOGY ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS PEPTIDES PERFORMING OPERATIONS SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES THEIR PREPARATION OR CHEMICAL WORKING-UP TRANSPORTING
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Beschreibung
Zusammenfassung:	A modified compound that has at least one further functional group, in particular a bio- or macromolecule, comprising at least one x-fold (x 1) chemoselectively incorporated phosphoramidate group of general formula (I), NPO(OR1) (OR1′), and/or at least one x-fold (x 1) chemoselectively incorporated phosphonamide group of general formula (Ia), NPO(R1)(OR1′). R1 and R1′ is selected from the group containing glycerol, polyglycerol, PEG polymers of the general empirical formula C2nH4n+2On+1 with n 1, Cn-alkyl chains with n 1; functionalized Cn-alkyl chains with n 1, aryls, heteroaryl, silyl, lipids, fluorophores, saccharides, peptides, crown ethers, or a linker, which links the aforementioned groups. R1 and R1′ can be identical to or different from one another.