BRIDGED COMPOUNDS AS HIV INTEGRASE INHIBITORS
Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: the asterisk * in Q denotes the point of attachment to the rest of the compound; and n, L1, L2, X1, X2, χ3, Y, Z, R1, R2 and R3 are defined herein. The N compounds are useful for the prophylaxis or treatment of...
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| creator | SU DAI-SHI LIM JOHN WAI JOHN S LOUGHRAN H. MARIE KIM BOYOUNG WILLIAMS PETER D VENKATRAMAN SHANKAR THOMPSON WAYNE ISAACS RICHARD C.A EMBREY MARK W |
| description | Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: the asterisk * in Q denotes the point of attachment to the rest of the compound; and n, L1, L2, X1, X2, χ3, Y, Z, R1, R2 and R3 are defined herein. The N compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. |
| format | Patent |
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MARIE ; KIM BOYOUNG ; WILLIAMS PETER D ; VENKATRAMAN SHANKAR ; THOMPSON WAYNE ; ISAACS RICHARD C.A ; EMBREY MARK W</creatorcontrib><description>Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: the asterisk * in Q denotes the point of attachment to the rest of the compound; and n, L1, L2, X1, X2, χ3, Y, Z, R1, R2 and R3 are defined herein. The N compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. 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MARIE</creatorcontrib><creatorcontrib>KIM BOYOUNG</creatorcontrib><creatorcontrib>WILLIAMS PETER D</creatorcontrib><creatorcontrib>VENKATRAMAN SHANKAR</creatorcontrib><creatorcontrib>THOMPSON WAYNE</creatorcontrib><creatorcontrib>ISAACS RICHARD C.A</creatorcontrib><creatorcontrib>EMBREY MARK W</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SU DAI-SHI</au><au>LIM JOHN</au><au>WAI JOHN S</au><au>LOUGHRAN H. MARIE</au><au>KIM BOYOUNG</au><au>WILLIAMS PETER D</au><au>VENKATRAMAN SHANKAR</au><au>THOMPSON WAYNE</au><au>ISAACS RICHARD C.A</au><au>EMBREY MARK W</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BRIDGED COMPOUNDS AS HIV INTEGRASE INHIBITORS</title><date>2012-01-26</date><risdate>2012</risdate><abstract>Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: the asterisk * in Q denotes the point of attachment to the rest of the compound; and n, L1, L2, X1, X2, χ3, Y, Z, R1, R2 and R3 are defined herein. The N compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | BRIDGED COMPOUNDS AS HIV INTEGRASE INHIBITORS |
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