Methods of identifying agents that modulate phenotypes related to disruptions, of a gene encoding PRO235 polypeptide
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, P...
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| creator | STALA JOY ANNE GREEN LESLIE JANE MONTGOMERY CHARLES VOGEL PETER MCLAIN DINA REBECCA DE SAUVAGE FREDERIC J CULBERTSON LING LING HORNER ALLISON ANNE BYERS TOWNSEND TERESA GAIL COMBS KATHERIN E PHILLIPS HEIDI TANG TRACY TZU-LING BOLLINGER KRISTI RAE EDWARDS JOEL CUNNINGHAM JAIME-JO SHI ZHENG-ZHENG GIRGIS ROSEMARY MINZE LAURIE JEANETTE SPARKS MARY JEAN SEVAUX TRACY ELLEN WILLIS PAYNE BOBBY JOE |
| description | The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; cyc abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities. |
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Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; cyc abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.</description><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMBINATORIAL CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120105&DB=EPODOC&CC=US&NR=2012005766A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120105&DB=EPODOC&CC=US&NR=2012005766A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>STALA JOY ANNE</creatorcontrib><creatorcontrib>GREEN LESLIE JANE</creatorcontrib><creatorcontrib>MONTGOMERY CHARLES</creatorcontrib><creatorcontrib>VOGEL PETER</creatorcontrib><creatorcontrib>MCLAIN DINA REBECCA</creatorcontrib><creatorcontrib>DE SAUVAGE FREDERIC J</creatorcontrib><creatorcontrib>CULBERTSON LING LING</creatorcontrib><creatorcontrib>HORNER ALLISON ANNE BYERS</creatorcontrib><creatorcontrib>TOWNSEND TERESA GAIL</creatorcontrib><creatorcontrib>COMBS KATHERIN E</creatorcontrib><creatorcontrib>PHILLIPS HEIDI</creatorcontrib><creatorcontrib>TANG TRACY TZU-LING</creatorcontrib><creatorcontrib>BOLLINGER KRISTI RAE</creatorcontrib><creatorcontrib>EDWARDS JOEL</creatorcontrib><creatorcontrib>CUNNINGHAM JAIME-JO</creatorcontrib><creatorcontrib>SHI ZHENG-ZHENG</creatorcontrib><creatorcontrib>GIRGIS ROSEMARY</creatorcontrib><creatorcontrib>MINZE LAURIE JEANETTE</creatorcontrib><creatorcontrib>SPARKS MARY JEAN</creatorcontrib><creatorcontrib>SEVAUX TRACY ELLEN WILLIS</creatorcontrib><creatorcontrib>PAYNE BOBBY JOE</creatorcontrib><title>Methods of identifying agents that modulate phenotypes related to disruptions, of a gene encoding PRO235 polypeptide</title><description>The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; cyc abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMBINATORIAL CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjLsKwkAQRdNYiPoPA7YKeZCkFlFsRPFRhyUzSRbizpKZFPl7N-AHWN3L5dyzjPRK2jEKcAMWyaltJutaMG3oAtoZhQ_j2Bsl8B051smTwEDzgqAMaGUYvVp2sps1BsKXgFzNOKvuj1ua5eC5D8_AIa2jRWN6oc0vV9H2fHodL3vyXJF4UweBVu9nGidpHOdlURyS7D_qC4O9RVM</recordid><startdate>20120105</startdate><enddate>20120105</enddate><creator>STALA JOY ANNE</creator><creator>GREEN LESLIE JANE</creator><creator>MONTGOMERY CHARLES</creator><creator>VOGEL PETER</creator><creator>MCLAIN DINA REBECCA</creator><creator>DE SAUVAGE FREDERIC J</creator><creator>CULBERTSON LING LING</creator><creator>HORNER ALLISON ANNE BYERS</creator><creator>TOWNSEND TERESA GAIL</creator><creator>COMBS KATHERIN E</creator><creator>PHILLIPS HEIDI</creator><creator>TANG TRACY TZU-LING</creator><creator>BOLLINGER KRISTI RAE</creator><creator>EDWARDS JOEL</creator><creator>CUNNINGHAM JAIME-JO</creator><creator>SHI ZHENG-ZHENG</creator><creator>GIRGIS ROSEMARY</creator><creator>MINZE LAURIE JEANETTE</creator><creator>SPARKS MARY JEAN</creator><creator>SEVAUX TRACY ELLEN WILLIS</creator><creator>PAYNE BOBBY JOE</creator><scope>EVB</scope></search><sort><creationdate>20120105</creationdate><title>Methods of identifying agents that modulate phenotypes related to disruptions, of a gene encoding PRO235 polypeptide</title><author>STALA JOY ANNE ; 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Specifically, the present invention provides transgenic mice comprising disruptions in PRO188, PRO235, PRO266, PRO337, PRO361, PRO539, PRO698, PRO717, PRO846, PRO874, PRO98346, PRO1082, PRO1097, PRO1192, PRO1268, PRO1278, PRO1303, PRO1308, PRO1338, PRO1378, PRO1415, PRO1867, PRO1890, PRO3438, PRO19835, PRO36915, PRO36029, PRO4999, PRO5778, PRO5997, PRO6079, PRO6090, PRO7178, PRO21184, PRO7434, PRO9822, PRO9833, PRO9836, PRO9854, PRO9862, PRO10284, PRO37510, PRO35444, PRO20473, PRO21054 or PRO35246 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; cyc abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE |
| title | Methods of identifying agents that modulate phenotypes related to disruptions, of a gene encoding PRO235 polypeptide |
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