Pharmaceutical composition containing polypeptide fragments of serralysins

The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from t...

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Bibliographische Detailangaben
Hauptverfasser:	GONZALEZ JESUS REYES, RIOS GLORIA VELIZ, ROMERO MONICA BEQUET, GASMURI GONZALEZ CARIDAD ANAIS, GAVILONDO COWLEY JORGE VICTOR, ABRAHANTES PEREZ MARIA DEL CARMEN, SUAREZ JOSE GARCIA, DIAZ EDUARDO MARTINEZ, GONZALEZ LOPEZ LUIS JAVIER, SOSA MANUEL SELMAN-HOUSEIN, CASTELLANOS SERRA LISA ROSA, RIERA RAUL GOMEZ
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention is related to a composition capable of inhibiting the growth of tumoral cells of different histological origins and of activated endothelial cells. The components of said compositions are polypeptide fragments of the serralisins, corresponding to the C-terminal fragment, from the internal metionine trough the end of the molecule, which could be combined among them and optionally with the prodigiosins that potentiate the antitumoral effect of the composition. The prodigiosins in the composition could be at a concentration of 0.1-100 nM. The anti-proliferative action of this composition is mediated by apoptotic mechanism. It's "in vivo" administration has antitumoral, antiangiogenic and protective effect against malignant tumors.