Compositions and Methods for Producing Vascular Occlusion using a Solid-phase Platelet Binding Agent
The present invention relates generally to methods and compositions for targeting and delivering solid-phase platelet-dependent vascular occlusion agents. In particular, particles or coils or stents coated with platelet binding agents are directed to target vasculature, such as the vasculature of so...
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| creator | TIEGE PAUL B STEWART MICHAEL W PERSON ROLAND H HIRSCHE BRUCE GRIFFITH IRWIN J NOUJIAM ANTOINE |
| description | The present invention relates generally to methods and compositions for targeting and delivering solid-phase platelet-dependent vascular occlusion agents. In particular, particles or coils or stents coated with platelet binding agents are directed to target vasculature, such as the vasculature of solid tumor masses or AV-malformations or aneurysms or endoleaks; the solid-phase agent then binds and activates platelets, which in turn bind and activate other platelets. This process results in the rapid formation of a platelet-mediated thrombus about the solid-phase agent causing vessel occlusion. |
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | Compositions and Methods for Producing Vascular Occlusion using a Solid-phase Platelet Binding Agent |
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