RESTORATION OF ESTROGEN RECEPTOR-(ALPHA) ACTIVITY

RESTORATION OF ESTROGEN RECEPTOR-(ALPHA) ACTIVITY

One third of all breast cancers are estrogen receptor alpha (ERα) negative, have a poor overall prognosis and do not respond well to currently available endocrine therapies. Use of a Wnt5-α protein or a peptide thereof, such as a recombinant Wnt-5a protein or a Wnt-5a derived hexapeptide (Foxy-5) po...

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Hauptverfasser: FORD CAROLINE ELIZABETH, ANDERSSON TOMMY
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Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator FORD CAROLINE ELIZABETH
ANDERSSON TOMMY
description One third of all breast cancers are estrogen receptor alpha (ERα) negative, have a poor overall prognosis and do not respond well to currently available endocrine therapies. Use of a Wnt5-α protein or a peptide thereof, such as a recombinant Wnt-5a protein or a Wnt-5a derived hexapeptide (Foxy-5) possessing Wnt-5a signaling properties, enables restoration of ERα expression and makes it possible to treat such breast cancers with selective estrogen receptor modulators, such as tamoxifen, or aromatase inhibitors.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title RESTORATION OF ESTROGEN RECEPTOR-(ALPHA) ACTIVITY
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