HUMAN MONOCLONAL ANTIBODY NEUTRALIZING VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR AND USE THEREOF
The present invention relates to human monoclonal antibodies neutralizing vascular endothelial growth factor receptor and the use thereof. More specifically, relates to human ScFv molecules neutralizing vascular endothelial growth factor receptor, and a composition for inhibiting angiogenesis and a...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | CHO TOO-HYON RHA GEUN - BAE LEE DONG- SUP YOO HYEON- MI PARK MI-HEE KANG JEONG- EUN PARK YOUNG-WOO LEE JOON CHUL PYUN BO-JEONG KIM SEMI YUN CHAE-OK KOH SANG-SEOK KIM DO-YUN SHIM SANG-RYEOL LEE DONG-HEON JANG HYUN-SOOK SUL SAM-SOOK LEE WEON-SUP JEON JAE -WON KIM SUNG-WOO KWON YOUNG-GUEN KIM NAHM-JU YOO JIN-SAN KIM KWI-HWA |
| description | The present invention relates to human monoclonal antibodies neutralizing vascular endothelial growth factor receptor and the use thereof. More specifically, relates to human ScFv molecules neutralizing vascular endothelial growth factor receptor, and a composition for inhibiting angiogenesis and a composition for treating cancer, which contain the human ScFv molecules. The disclosed monoclonal antibody neutralizing vascular endothelial growth factor receptor shows excellent neutralizing ability in living cells, compared to that of a commercially available antibody against vascular endothelial growth factor receptor, and shows the ability to neutralize vascular endothelial growth factor receptor not only in humans, but also in mice and rats. Thus, the monoclonal antibody will be useful in anticancer studies and will be highly effective in cancer treatment. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US2011065176A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US2011065176A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US2011065176A13</originalsourceid><addsrcrecordid>eNqNyrEKwjAQgOEuDqK-w4Gz0CjW-UyvTSG9kzRRdClV4iRaqO-PFXwAp_8fvmlyNaFGhlpYtBVGC8i-2kt-BqbgHdrqUnEJR2x0sOiAOBdvyFYjLZ2cvIECtRcHjjQdvoOcQ2gIRuZIinkyuXePIS5-nSXLgrw2q9i_2jj03S0-47sNzTpVKs22apeh2vynPvsqNU0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>HUMAN MONOCLONAL ANTIBODY NEUTRALIZING VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR AND USE THEREOF</title><source>esp@cenet</source><creator>CHO TOO-HYON ; RHA GEUN - BAE ; LEE DONG- SUP ; YOO HYEON- MI ; PARK MI-HEE ; KANG JEONG- EUN ; PARK YOUNG-WOO ; LEE JOON CHUL ; PYUN BO-JEONG ; KIM SEMI ; YUN CHAE-OK ; KOH SANG-SEOK ; KIM DO-YUN ; SHIM SANG-RYEOL ; LEE DONG-HEON ; JANG HYUN-SOOK ; SUL SAM-SOOK ; LEE WEON-SUP ; JEON JAE -WON ; KIM SUNG-WOO ; KWON YOUNG-GUEN ; KIM NAHM-JU ; YOO JIN-SAN ; KIM KWI-HWA</creator><creatorcontrib>CHO TOO-HYON ; RHA GEUN - BAE ; LEE DONG- SUP ; YOO HYEON- MI ; PARK MI-HEE ; KANG JEONG- EUN ; PARK YOUNG-WOO ; LEE JOON CHUL ; PYUN BO-JEONG ; KIM SEMI ; YUN CHAE-OK ; KOH SANG-SEOK ; KIM DO-YUN ; SHIM SANG-RYEOL ; LEE DONG-HEON ; JANG HYUN-SOOK ; SUL SAM-SOOK ; LEE WEON-SUP ; JEON JAE -WON ; KIM SUNG-WOO ; KWON YOUNG-GUEN ; KIM NAHM-JU ; YOO JIN-SAN ; KIM KWI-HWA</creatorcontrib><description>The present invention relates to human monoclonal antibodies neutralizing vascular endothelial growth factor receptor and the use thereof. More specifically, relates to human ScFv molecules neutralizing vascular endothelial growth factor receptor, and a composition for inhibiting angiogenesis and a composition for treating cancer, which contain the human ScFv molecules. The disclosed monoclonal antibody neutralizing vascular endothelial growth factor receptor shows excellent neutralizing ability in living cells, compared to that of a commercially available antibody against vascular endothelial growth factor receptor, and shows the ability to neutralize vascular endothelial growth factor receptor not only in humans, but also in mice and rats. Thus, the monoclonal antibody will be useful in anticancer studies and will be highly effective in cancer treatment.</description><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; DERIVATIVES THEREOF ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PEPTIDES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; SUGARS ; VINEGAR ; WINE</subject><creationdate>2011</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110317&DB=EPODOC&CC=US&NR=2011065176A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20110317&DB=EPODOC&CC=US&NR=2011065176A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHO TOO-HYON</creatorcontrib><creatorcontrib>RHA GEUN - BAE</creatorcontrib><creatorcontrib>LEE DONG- SUP</creatorcontrib><creatorcontrib>YOO HYEON- MI</creatorcontrib><creatorcontrib>PARK MI-HEE</creatorcontrib><creatorcontrib>KANG JEONG- EUN</creatorcontrib><creatorcontrib>PARK YOUNG-WOO</creatorcontrib><creatorcontrib>LEE JOON CHUL</creatorcontrib><creatorcontrib>PYUN BO-JEONG</creatorcontrib><creatorcontrib>KIM SEMI</creatorcontrib><creatorcontrib>YUN CHAE-OK</creatorcontrib><creatorcontrib>KOH SANG-SEOK</creatorcontrib><creatorcontrib>KIM DO-YUN</creatorcontrib><creatorcontrib>SHIM SANG-RYEOL</creatorcontrib><creatorcontrib>LEE DONG-HEON</creatorcontrib><creatorcontrib>JANG HYUN-SOOK</creatorcontrib><creatorcontrib>SUL SAM-SOOK</creatorcontrib><creatorcontrib>LEE WEON-SUP</creatorcontrib><creatorcontrib>JEON JAE -WON</creatorcontrib><creatorcontrib>KIM SUNG-WOO</creatorcontrib><creatorcontrib>KWON YOUNG-GUEN</creatorcontrib><creatorcontrib>KIM NAHM-JU</creatorcontrib><creatorcontrib>YOO JIN-SAN</creatorcontrib><creatorcontrib>KIM KWI-HWA</creatorcontrib><title>HUMAN MONOCLONAL ANTIBODY NEUTRALIZING VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR AND USE THEREOF</title><description>The present invention relates to human monoclonal antibodies neutralizing vascular endothelial growth factor receptor and the use thereof. More specifically, relates to human ScFv molecules neutralizing vascular endothelial growth factor receptor, and a composition for inhibiting angiogenesis and a composition for treating cancer, which contain the human ScFv molecules. The disclosed monoclonal antibody neutralizing vascular endothelial growth factor receptor shows excellent neutralizing ability in living cells, compared to that of a commercially available antibody against vascular endothelial growth factor receptor, and shows the ability to neutralize vascular endothelial growth factor receptor not only in humans, but also in mice and rats. Thus, the monoclonal antibody will be useful in anticancer studies and will be highly effective in cancer treatment.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>DERIVATIVES THEREOF</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>SUGARS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2011</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAQgOEuDqK-w4Gz0CjW-UyvTSG9kzRRdClV4iRaqO-PFXwAp_8fvmlyNaFGhlpYtBVGC8i-2kt-BqbgHdrqUnEJR2x0sOiAOBdvyFYjLZ2cvIECtRcHjjQdvoOcQ2gIRuZIinkyuXePIS5-nSXLgrw2q9i_2jj03S0-47sNzTpVKs22apeh2vynPvsqNU0</recordid><startdate>20110317</startdate><enddate>20110317</enddate><creator>CHO TOO-HYON</creator><creator>RHA GEUN - BAE</creator><creator>LEE DONG- SUP</creator><creator>YOO HYEON- MI</creator><creator>PARK MI-HEE</creator><creator>KANG JEONG- EUN</creator><creator>PARK YOUNG-WOO</creator><creator>LEE JOON CHUL</creator><creator>PYUN BO-JEONG</creator><creator>KIM SEMI</creator><creator>YUN CHAE-OK</creator><creator>KOH SANG-SEOK</creator><creator>KIM DO-YUN</creator><creator>SHIM SANG-RYEOL</creator><creator>LEE DONG-HEON</creator><creator>JANG HYUN-SOOK</creator><creator>SUL SAM-SOOK</creator><creator>LEE WEON-SUP</creator><creator>JEON JAE -WON</creator><creator>KIM SUNG-WOO</creator><creator>KWON YOUNG-GUEN</creator><creator>KIM NAHM-JU</creator><creator>YOO JIN-SAN</creator><creator>KIM KWI-HWA</creator><scope>EVB</scope></search><sort><creationdate>20110317</creationdate><title>HUMAN MONOCLONAL ANTIBODY NEUTRALIZING VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR AND USE THEREOF</title><author>CHO TOO-HYON ; RHA GEUN - BAE ; LEE DONG- SUP ; YOO HYEON- MI ; PARK MI-HEE ; KANG JEONG- EUN ; PARK YOUNG-WOO ; LEE JOON CHUL ; PYUN BO-JEONG ; KIM SEMI ; YUN CHAE-OK ; KOH SANG-SEOK ; KIM DO-YUN ; SHIM SANG-RYEOL ; LEE DONG-HEON ; JANG HYUN-SOOK ; SUL SAM-SOOK ; LEE WEON-SUP ; JEON JAE -WON ; KIM SUNG-WOO ; KWON YOUNG-GUEN ; KIM NAHM-JU ; YOO JIN-SAN ; KIM KWI-HWA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2011065176A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2011</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>DERIVATIVES THEREOF</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>SUGARS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>CHO TOO-HYON</creatorcontrib><creatorcontrib>RHA GEUN - BAE</creatorcontrib><creatorcontrib>LEE DONG- SUP</creatorcontrib><creatorcontrib>YOO HYEON- MI</creatorcontrib><creatorcontrib>PARK MI-HEE</creatorcontrib><creatorcontrib>KANG JEONG- EUN</creatorcontrib><creatorcontrib>PARK YOUNG-WOO</creatorcontrib><creatorcontrib>LEE JOON CHUL</creatorcontrib><creatorcontrib>PYUN BO-JEONG</creatorcontrib><creatorcontrib>KIM SEMI</creatorcontrib><creatorcontrib>YUN CHAE-OK</creatorcontrib><creatorcontrib>KOH SANG-SEOK</creatorcontrib><creatorcontrib>KIM DO-YUN</creatorcontrib><creatorcontrib>SHIM SANG-RYEOL</creatorcontrib><creatorcontrib>LEE DONG-HEON</creatorcontrib><creatorcontrib>JANG HYUN-SOOK</creatorcontrib><creatorcontrib>SUL SAM-SOOK</creatorcontrib><creatorcontrib>LEE WEON-SUP</creatorcontrib><creatorcontrib>JEON JAE -WON</creatorcontrib><creatorcontrib>KIM SUNG-WOO</creatorcontrib><creatorcontrib>KWON YOUNG-GUEN</creatorcontrib><creatorcontrib>KIM NAHM-JU</creatorcontrib><creatorcontrib>YOO JIN-SAN</creatorcontrib><creatorcontrib>KIM KWI-HWA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CHO TOO-HYON</au><au>RHA GEUN - BAE</au><au>LEE DONG- SUP</au><au>YOO HYEON- MI</au><au>PARK MI-HEE</au><au>KANG JEONG- EUN</au><au>PARK YOUNG-WOO</au><au>LEE JOON CHUL</au><au>PYUN BO-JEONG</au><au>KIM SEMI</au><au>YUN CHAE-OK</au><au>KOH SANG-SEOK</au><au>KIM DO-YUN</au><au>SHIM SANG-RYEOL</au><au>LEE DONG-HEON</au><au>JANG HYUN-SOOK</au><au>SUL SAM-SOOK</au><au>LEE WEON-SUP</au><au>JEON JAE -WON</au><au>KIM SUNG-WOO</au><au>KWON YOUNG-GUEN</au><au>KIM NAHM-JU</au><au>YOO JIN-SAN</au><au>KIM KWI-HWA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HUMAN MONOCLONAL ANTIBODY NEUTRALIZING VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR AND USE THEREOF</title><date>2011-03-17</date><risdate>2011</risdate><abstract>The present invention relates to human monoclonal antibodies neutralizing vascular endothelial growth factor receptor and the use thereof. More specifically, relates to human ScFv molecules neutralizing vascular endothelial growth factor receptor, and a composition for inhibiting angiogenesis and a composition for treating cancer, which contain the human ScFv molecules. The disclosed monoclonal antibody neutralizing vascular endothelial growth factor receptor shows excellent neutralizing ability in living cells, compared to that of a commercially available antibody against vascular endothelial growth factor receptor, and shows the ability to neutralize vascular endothelial growth factor receptor not only in humans, but also in mice and rats. Thus, the monoclonal antibody will be useful in anticancer studies and will be highly effective in cancer treatment.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_US2011065176A1 |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE |
| title | HUMAN MONOCLONAL ANTIBODY NEUTRALIZING VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR AND USE THEREOF |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T18%3A23%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=CHO%20TOO-HYON&rft.date=2011-03-17&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EUS2011065176A1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |