BIOCHIP FOR ELECTROPHYSIOLOGICAL MEASUREMENTS
The present invention relates to a substrate for measuring the electrophysiological properties of ion-channels located in cell membranes. The substrate is typically used in a screening device providing high-throughput industrialized measurements for studying ionic currents, particularly useful in th...
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| creator | SORENSEN CLAUS BIRGER |
| description | The present invention relates to a substrate for measuring the electrophysiological properties of ion-channels located in cell membranes. The substrate is typically used in a screening device providing high-throughput industrialized measurements for studying ionic currents, particularly useful in the screening of drugs acting on the ion-channels found in cell membranes, by providing many parallel simultaneous and independent measurements. The substrate has one or a plurality of individually addressable electrode sites, each comprising one or more individual elongated nanosize electrodes, capable of penetrating the cell membranes during application of cells directly on the substrate, thus providing one or more low resistance contacts to the interior of the cells. This allows for an easy and effective low-cost solution to automated patch clamp measurements in the whole-cell configuration, using both single as well as multi-electrode contacts to each cell. The invention also makes ensemble measurements on multiple cells in parallel possible. |
| format | Patent |
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The substrate is typically used in a screening device providing high-throughput industrialized measurements for studying ionic currents, particularly useful in the screening of drugs acting on the ion-channels found in cell membranes, by providing many parallel simultaneous and independent measurements. The substrate has one or a plurality of individually addressable electrode sites, each comprising one or more individual elongated nanosize electrodes, capable of penetrating the cell membranes during application of cells directly on the substrate, thus providing one or more low resistance contacts to the interior of the cells. This allows for an easy and effective low-cost solution to automated patch clamp measurements in the whole-cell configuration, using both single as well as multi-electrode contacts to each cell. The invention also makes ensemble measurements on multiple cells in parallel possible.</description><language>eng</language><subject>APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY ; APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL ; BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PERFORMING OPERATIONS ; PHYSICS ; PROCESSES FOR APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TOSURFACES, IN GENERAL ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPIRITS ; SPRAYING OR ATOMISING IN GENERAL ; TESTING ; TRANSPORTING ; VINEGAR ; WINE</subject><creationdate>2010</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20101230&DB=EPODOC&CC=US&NR=2010330612A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20101230&DB=EPODOC&CC=US&NR=2010330612A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SORENSEN CLAUS BIRGER</creatorcontrib><title>BIOCHIP FOR ELECTROPHYSIOLOGICAL MEASUREMENTS</title><description>The present invention relates to a substrate for measuring the electrophysiological properties of ion-channels located in cell membranes. The substrate is typically used in a screening device providing high-throughput industrialized measurements for studying ionic currents, particularly useful in the screening of drugs acting on the ion-channels found in cell membranes, by providing many parallel simultaneous and independent measurements. The substrate has one or a plurality of individually addressable electrode sites, each comprising one or more individual elongated nanosize electrodes, capable of penetrating the cell membranes during application of cells directly on the substrate, thus providing one or more low resistance contacts to the interior of the cells. This allows for an easy and effective low-cost solution to automated patch clamp measurements in the whole-cell configuration, using both single as well as multi-electrode contacts to each cell. The invention also makes ensemble measurements on multiple cells in parallel possible.</description><subject>APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY</subject><subject>APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PERFORMING OPERATIONS</subject><subject>PHYSICS</subject><subject>PROCESSES FOR APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TOSURFACES, IN GENERAL</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPIRITS</subject><subject>SPRAYING OR ATOMISING IN GENERAL</subject><subject>TESTING</subject><subject>TRANSPORTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2010</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNB18vR39vAMUHDzD1Jw9XF1DgnyD_CIDPb09_F393R29FHwdXUMDg1y9XX1CwnmYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXxocFGBoYGxsYGZoZGjobGxKkCAHm9Jq8</recordid><startdate>20101230</startdate><enddate>20101230</enddate><creator>SORENSEN CLAUS BIRGER</creator><scope>EVB</scope></search><sort><creationdate>20101230</creationdate><title>BIOCHIP FOR ELECTROPHYSIOLOGICAL MEASUREMENTS</title><author>SORENSEN CLAUS BIRGER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2010330612A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2010</creationdate><topic>APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY</topic><topic>APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PERFORMING OPERATIONS</topic><topic>PHYSICS</topic><topic>PROCESSES FOR APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TOSURFACES, IN GENERAL</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPIRITS</topic><topic>SPRAYING OR ATOMISING IN GENERAL</topic><topic>TESTING</topic><topic>TRANSPORTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>SORENSEN CLAUS BIRGER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SORENSEN CLAUS BIRGER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BIOCHIP FOR ELECTROPHYSIOLOGICAL MEASUREMENTS</title><date>2010-12-30</date><risdate>2010</risdate><abstract>The present invention relates to a substrate for measuring the electrophysiological properties of ion-channels located in cell membranes. The substrate is typically used in a screening device providing high-throughput industrialized measurements for studying ionic currents, particularly useful in the screening of drugs acting on the ion-channels found in cell membranes, by providing many parallel simultaneous and independent measurements. The substrate has one or a plurality of individually addressable electrode sites, each comprising one or more individual elongated nanosize electrodes, capable of penetrating the cell membranes during application of cells directly on the substrate, thus providing one or more low resistance contacts to the interior of the cells. This allows for an easy and effective low-cost solution to automated patch clamp measurements in the whole-cell configuration, using both single as well as multi-electrode contacts to each cell. The invention also makes ensemble measurements on multiple cells in parallel possible.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PERFORMING OPERATIONS PHYSICS PROCESSES FOR APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TOSURFACES, IN GENERAL PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS SPRAYING OR ATOMISING IN GENERAL TESTING TRANSPORTING VINEGAR WINE |
| title | BIOCHIP FOR ELECTROPHYSIOLOGICAL MEASUREMENTS |
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