PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES

PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES

The present invention relates to methods of making compounds that inhibit 11-hydroxysteroid dehydrogenase type 1 enzyme (11-HSD1). One method comprises (a) contacting a compound of formula (II) sequentially with a chiral base in the presence of an amine, and an alkylating agent R3-LG, (b) contacting...

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Hauptverfasser: FRIZZLE MATTHEW J, MONIZ GEORGE A, FAUL MARGARET, LARROW JAY, BERNARD CHARLES, NANI ROGER, MARTINELLI MICHAEL
Format: Patent
Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator FRIZZLE MATTHEW J
MONIZ GEORGE A
FAUL MARGARET
LARROW JAY
BERNARD CHARLES
NANI ROGER
MARTINELLI MICHAEL
description The present invention relates to methods of making compounds that inhibit 11-hydroxysteroid dehydrogenase type 1 enzyme (11-HSD1). One method comprises (a) contacting a compound of formula (II) sequentially with a chiral base in the presence of an amine, and an alkylating agent R3-LG, (b) contacting the product of (a) with an acid to form a salt, and (c) reacting the salt with a base to form the compound of formula (I), wherein Z, R1, R2, and R3 are defined herein.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title PROCESS FOR MAKING SUBSTITUTED 2-AMINO-THIAZOLONES
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