FUSED RING HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment...
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| creator | THOMAS, JR. JAMES BARNWELL AMATO GEORGE SALVATORE MCNAUGHTON-SMITH GRANT ANDREW |
| description | Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. More particularly, the invention provides quinazolinone, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, bipolar disorders, trigeminal neuralgia, spasticity, mood disorders, brain tumors, psychotic disorders, myokymia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, age-related memory loss, learning deficiencies, anxiety and motor neuron diseases, maintaining bladder control or treating urinary incontinence) and as neuroprotective agents (e.g., to prevent stroke and the like) by modulating potassium channels associated with the onset or recurrence of the indicated conditions. |
| format | Patent |
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JAMES BARNWELL ; AMATO GEORGE SALVATORE ; MCNAUGHTON-SMITH GRANT ANDREW</creatorcontrib><description>Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. 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JAMES BARNWELL</creatorcontrib><creatorcontrib>AMATO GEORGE SALVATORE</creatorcontrib><creatorcontrib>MCNAUGHTON-SMITH GRANT ANDREW</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>THOMAS, JR. JAMES BARNWELL</au><au>AMATO GEORGE SALVATORE</au><au>MCNAUGHTON-SMITH GRANT ANDREW</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FUSED RING HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS</title><date>2010-10-28</date><risdate>2010</risdate><abstract>Compounds, compositions and methods are provided which are useful in the treatment of diseases through the modulation of potassium ion flux through voltage-dependent potassium channels. 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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | FUSED RING HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS |
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