COLORIMETRIC METHOD AND KIT FOR THE DETECTION OF SPECIFIC NUCLEIC ACID SEQUENCES USING METAL NANOPARTICLES FUNCTIONALIZED WITH MODIFIED OLIGONUCLEOTIDES
The present invention relates to a colorimetric method for the detection of specific nucleic acids sequences, including mutations or single nucleotide polymorphisms within nucleic acid sequences, through the aggregation of nanoparticles functionalized with modified oligonucleotides, induced by an in...
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| creator | RAMOS FRANCO TAVARES JOSE RICARDO DE LEOAO FLORES ALCINO ORFEU REIMAO PINTO DE FRANCA DORIA GONCALO MARIA RIBEIRO VIANA BAPTISTA PEDRO MIGUEL |
| description | The present invention relates to a colorimetric method for the detection of specific nucleic acids sequences, including mutations or single nucleotide polymorphisms within nucleic acid sequences, through the aggregation of nanoparticles functionalized with modified oligonucleotides, induced by an increase of the medium's ionic strength. Another aspect of the present invention relates with the development of a kit based on the method of the present invention, allowing for a quick and easy detection of specific nucleic acids sequences, including mutations or single nucleotide polymorphisms within nucleic acid sequences. |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE |
| title | COLORIMETRIC METHOD AND KIT FOR THE DETECTION OF SPECIFIC NUCLEIC ACID SEQUENCES USING METAL NANOPARTICLES FUNCTIONALIZED WITH MODIFIED OLIGONUCLEOTIDES |
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