Pharmaceutical Formulation Comprising Metformin and Repaglinide

The invention is related to a pharmaceutical composition comprising repaglinide in combination with metformin or a salt thereof in unit dosage form wherein a pre-formulation of the repaglinide has a pH independent dissolution profile and a relative humidity of less than about 25% prior to mixing wit...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: RASMUSSEN STELLA RUDKJAER, JACOBSEN LENE ORUP, KNUDSEN BREIAN, HOJGAARD BENT
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The invention is related to a pharmaceutical composition comprising repaglinide in combination with metformin or a salt thereof in unit dosage form wherein a pre-formulation of the repaglinide has a pH independent dissolution profile and a relative humidity of less than about 25% prior to mixing with the metformin or a salt thereof; and optionally one or more pharmaceutically acceptable excipients and to a method for its preparation.