PRODRUGS OF DIPHENYL OX-INDOL-2-ONE COMPOUNDS

The present application discloses prodrugs of substituted 3,3-diphenyl-1,3-dihydro-indol-2-one compounds having the general formula (I). The 4-position of the phenyl moieties and the N-position of the indole represent useful handles for the introduction of particular prodrug groups, in particular th...

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Hauptverfasser: CHRISTENSEN METTE KNAK, IKAUNIEKS MARTINS, LOZA EINARS, BJOERKLING FREDRIK, GAILITE VIJA, ZAICHENKO ANDREI, MADRE MARINA, KALVINSH IVARS
Format: Patent
Sprache:eng
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Zusammenfassung:The present application discloses prodrugs of substituted 3,3-diphenyl-1,3-dihydro-indol-2-one compounds having the general formula (I). The 4-position of the phenyl moieties and the N-position of the indole represent useful handles for the introduction of particular prodrug groups, in particular those comprising an amino acid moiety. The prodrug compounds are believed to be useful for the treatment of cancer in a mammal, possibly in combination with one or more other chemotherapeutic agents. The application also discloses the compounds for use in a method of treating a mammal suffering from or being susceptible to cancer