Differentially expressed tumour-specific polypeptides for use in the diagnosis and treatment of cancer
The invention relates to agents and methods for the diagnosis, prognosis and treatment of cancer. Specifically, the invention relates to the use of nucleic and amino acid sequences encoding transmembrane superfamily member 6 (TM4SF6), synaptophysin like protein (SYPL), stomatin like 2 (STOML2), Ras...
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| creator | FUCHS MIRIAM MEUER JOERN LAMER STEPHANIE PEREZ SILVIA TORTOLA STEDRONSKY KATRIN FOTIADIS NIKOLETA-KYRIAKI SEIBERT VOLKER HEIM STEFFEN LEHNHERR-ILINA TATIANA BUSCHMANN THOMAS ROTHMANN-COSIC KIRSTEN |
| description | The invention relates to agents and methods for the diagnosis, prognosis and treatment of cancer. Specifically, the invention relates to the use of nucleic and amino acid sequences encoding transmembrane superfamily member 6 (TM4SF6), synaptophysin like protein (SYPL), stomatin like 2 (STOML2), Ras related GTP binding protein RAGA), nucleotide sensitive chloride channel 1A (CLNS1A), prion protein (p27-30) (PRNP), guanine nucleotide binding protein beta 2-like 1 (GNB2L1), guanine nucleotide binding protein 4 (GNG4), integral membrane protein 2B (ITM2B), integral membrane protein 1 (ITM1), transmembrane 9 superfamily member 2 (TM9SF2), opiate receptor-like 1 protein (OPRL1), low density lipoprotein receptor-related protein 4 (LRP4), human glomerular epithelial protein 1 (GLEPP1), toll-like receptor 3 (TLR3), and/or zona pellucida glycoprotein 3A (ZP3) for the diagnosis of both early and late stage non-steroid specific cancers, cancer prognosis, as well as screening for therapeutic agents that regulate the gene expression and/or biological activity of said proteins. This invention further relates to the biological technologies designed to inhibit the gene expression and/or biological activity of said proteins including using agents identified in screening assays described herein, vector delivery of antisense polynucleotide sequences, and antibody targeting of said proteins. In specific embodiments, the proteins are of human origin. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_US2009252721A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>US2009252721A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_US2009252721A13</originalsourceid><addsrcrecordid>eNqNjL0KwjAURrs4iPoOF5wLNSLiKP7grs7lkn7RC2kSclOwb28HH8DpLOeceeXO4hwyQhH2fiR8UoYqOipDH4dca4IVJ5ZS9GNCKtJBycVMg4IkUHmDOuFXiCpKHKYyg0s_LSk6shws8rKaOfaK1Y-Lan29PE63Gim20MQWAaV93k3THMzO7M3muNn-Z30B90VBOA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Differentially expressed tumour-specific polypeptides for use in the diagnosis and treatment of cancer</title><source>esp@cenet</source><creator>FUCHS MIRIAM ; MEUER JOERN ; LAMER STEPHANIE ; PEREZ SILVIA TORTOLA ; STEDRONSKY KATRIN ; FOTIADIS NIKOLETA-KYRIAKI ; SEIBERT VOLKER ; HEIM STEFFEN ; LEHNHERR-ILINA TATIANA ; BUSCHMANN THOMAS ; ROTHMANN-COSIC KIRSTEN</creator><creatorcontrib>FUCHS MIRIAM ; MEUER JOERN ; LAMER STEPHANIE ; PEREZ SILVIA TORTOLA ; STEDRONSKY KATRIN ; FOTIADIS NIKOLETA-KYRIAKI ; SEIBERT VOLKER ; HEIM STEFFEN ; LEHNHERR-ILINA TATIANA ; BUSCHMANN THOMAS ; ROTHMANN-COSIC KIRSTEN</creatorcontrib><description>The invention relates to agents and methods for the diagnosis, prognosis and treatment of cancer. Specifically, the invention relates to the use of nucleic and amino acid sequences encoding transmembrane superfamily member 6 (TM4SF6), synaptophysin like protein (SYPL), stomatin like 2 (STOML2), Ras related GTP binding protein RAGA), nucleotide sensitive chloride channel 1A (CLNS1A), prion protein (p27-30) (PRNP), guanine nucleotide binding protein beta 2-like 1 (GNB2L1), guanine nucleotide binding protein 4 (GNG4), integral membrane protein 2B (ITM2B), integral membrane protein 1 (ITM1), transmembrane 9 superfamily member 2 (TM9SF2), opiate receptor-like 1 protein (OPRL1), low density lipoprotein receptor-related protein 4 (LRP4), human glomerular epithelial protein 1 (GLEPP1), toll-like receptor 3 (TLR3), and/or zona pellucida glycoprotein 3A (ZP3) for the diagnosis of both early and late stage non-steroid specific cancers, cancer prognosis, as well as screening for therapeutic agents that regulate the gene expression and/or biological activity of said proteins. This invention further relates to the biological technologies designed to inhibit the gene expression and/or biological activity of said proteins including using agents identified in screening assays described herein, vector delivery of antisense polynucleotide sequences, and antibody targeting of said proteins. In specific embodiments, the proteins are of human origin.</description><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMBINATORIAL CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES ; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES ; MEASURING ; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PHYSICS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES OF PREPARING SUCH COMPOSITIONS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; TESTING ; VINEGAR ; WINE</subject><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20091008&DB=EPODOC&CC=US&NR=2009252721A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20091008&DB=EPODOC&CC=US&NR=2009252721A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FUCHS MIRIAM</creatorcontrib><creatorcontrib>MEUER JOERN</creatorcontrib><creatorcontrib>LAMER STEPHANIE</creatorcontrib><creatorcontrib>PEREZ SILVIA TORTOLA</creatorcontrib><creatorcontrib>STEDRONSKY KATRIN</creatorcontrib><creatorcontrib>FOTIADIS NIKOLETA-KYRIAKI</creatorcontrib><creatorcontrib>SEIBERT VOLKER</creatorcontrib><creatorcontrib>HEIM STEFFEN</creatorcontrib><creatorcontrib>LEHNHERR-ILINA TATIANA</creatorcontrib><creatorcontrib>BUSCHMANN THOMAS</creatorcontrib><creatorcontrib>ROTHMANN-COSIC KIRSTEN</creatorcontrib><title>Differentially expressed tumour-specific polypeptides for use in the diagnosis and treatment of cancer</title><description>The invention relates to agents and methods for the diagnosis, prognosis and treatment of cancer. Specifically, the invention relates to the use of nucleic and amino acid sequences encoding transmembrane superfamily member 6 (TM4SF6), synaptophysin like protein (SYPL), stomatin like 2 (STOML2), Ras related GTP binding protein RAGA), nucleotide sensitive chloride channel 1A (CLNS1A), prion protein (p27-30) (PRNP), guanine nucleotide binding protein beta 2-like 1 (GNB2L1), guanine nucleotide binding protein 4 (GNG4), integral membrane protein 2B (ITM2B), integral membrane protein 1 (ITM1), transmembrane 9 superfamily member 2 (TM9SF2), opiate receptor-like 1 protein (OPRL1), low density lipoprotein receptor-related protein 4 (LRP4), human glomerular epithelial protein 1 (GLEPP1), toll-like receptor 3 (TLR3), and/or zona pellucida glycoprotein 3A (ZP3) for the diagnosis of both early and late stage non-steroid specific cancers, cancer prognosis, as well as screening for therapeutic agents that regulate the gene expression and/or biological activity of said proteins. This invention further relates to the biological technologies designed to inhibit the gene expression and/or biological activity of said proteins including using agents identified in screening assays described herein, vector delivery of antisense polynucleotide sequences, and antibody targeting of said proteins. In specific embodiments, the proteins are of human origin.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMBINATORIAL CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</subject><subject>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</subject><subject>MEASURING</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PHYSICS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>TESTING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2009</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjL0KwjAURrs4iPoOF5wLNSLiKP7grs7lkn7RC2kSclOwb28HH8DpLOeceeXO4hwyQhH2fiR8UoYqOipDH4dca4IVJ5ZS9GNCKtJBycVMg4IkUHmDOuFXiCpKHKYyg0s_LSk6shws8rKaOfaK1Y-Lan29PE63Gim20MQWAaV93k3THMzO7M3muNn-Z30B90VBOA</recordid><startdate>20091008</startdate><enddate>20091008</enddate><creator>FUCHS MIRIAM</creator><creator>MEUER JOERN</creator><creator>LAMER STEPHANIE</creator><creator>PEREZ SILVIA TORTOLA</creator><creator>STEDRONSKY KATRIN</creator><creator>FOTIADIS NIKOLETA-KYRIAKI</creator><creator>SEIBERT VOLKER</creator><creator>HEIM STEFFEN</creator><creator>LEHNHERR-ILINA TATIANA</creator><creator>BUSCHMANN THOMAS</creator><creator>ROTHMANN-COSIC KIRSTEN</creator><scope>EVB</scope></search><sort><creationdate>20091008</creationdate><title>Differentially expressed tumour-specific polypeptides for use in the diagnosis and treatment of cancer</title><author>FUCHS MIRIAM ; MEUER JOERN ; LAMER STEPHANIE ; PEREZ SILVIA TORTOLA ; STEDRONSKY KATRIN ; FOTIADIS NIKOLETA-KYRIAKI ; SEIBERT VOLKER ; HEIM STEFFEN ; LEHNHERR-ILINA TATIANA ; BUSCHMANN THOMAS ; ROTHMANN-COSIC KIRSTEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2009252721A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2009</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMBINATORIAL CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES</topic><topic>LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES</topic><topic>MEASURING</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PHYSICS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>TESTING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>FUCHS MIRIAM</creatorcontrib><creatorcontrib>MEUER JOERN</creatorcontrib><creatorcontrib>LAMER STEPHANIE</creatorcontrib><creatorcontrib>PEREZ SILVIA TORTOLA</creatorcontrib><creatorcontrib>STEDRONSKY KATRIN</creatorcontrib><creatorcontrib>FOTIADIS NIKOLETA-KYRIAKI</creatorcontrib><creatorcontrib>SEIBERT VOLKER</creatorcontrib><creatorcontrib>HEIM STEFFEN</creatorcontrib><creatorcontrib>LEHNHERR-ILINA TATIANA</creatorcontrib><creatorcontrib>BUSCHMANN THOMAS</creatorcontrib><creatorcontrib>ROTHMANN-COSIC KIRSTEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FUCHS MIRIAM</au><au>MEUER JOERN</au><au>LAMER STEPHANIE</au><au>PEREZ SILVIA TORTOLA</au><au>STEDRONSKY KATRIN</au><au>FOTIADIS NIKOLETA-KYRIAKI</au><au>SEIBERT VOLKER</au><au>HEIM STEFFEN</au><au>LEHNHERR-ILINA TATIANA</au><au>BUSCHMANN THOMAS</au><au>ROTHMANN-COSIC KIRSTEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Differentially expressed tumour-specific polypeptides for use in the diagnosis and treatment of cancer</title><date>2009-10-08</date><risdate>2009</risdate><abstract>The invention relates to agents and methods for the diagnosis, prognosis and treatment of cancer. Specifically, the invention relates to the use of nucleic and amino acid sequences encoding transmembrane superfamily member 6 (TM4SF6), synaptophysin like protein (SYPL), stomatin like 2 (STOML2), Ras related GTP binding protein RAGA), nucleotide sensitive chloride channel 1A (CLNS1A), prion protein (p27-30) (PRNP), guanine nucleotide binding protein beta 2-like 1 (GNB2L1), guanine nucleotide binding protein 4 (GNG4), integral membrane protein 2B (ITM2B), integral membrane protein 1 (ITM1), transmembrane 9 superfamily member 2 (TM9SF2), opiate receptor-like 1 protein (OPRL1), low density lipoprotein receptor-related protein 4 (LRP4), human glomerular epithelial protein 1 (GLEPP1), toll-like receptor 3 (TLR3), and/or zona pellucida glycoprotein 3A (ZP3) for the diagnosis of both early and late stage non-steroid specific cancers, cancer prognosis, as well as screening for therapeutic agents that regulate the gene expression and/or biological activity of said proteins. This invention further relates to the biological technologies designed to inhibit the gene expression and/or biological activity of said proteins including using agents identified in screening assays described herein, vector delivery of antisense polynucleotide sequences, and antibody targeting of said proteins. In specific embodiments, the proteins are of human origin.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMBINATORIAL CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICOLIBRARIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE |
| title | Differentially expressed tumour-specific polypeptides for use in the diagnosis and treatment of cancer |
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