Conjugates with Anti-Inflammatory Activity

Compounds represented by Formula I: wherein M represents a macrolide subunit of the substructure VIII: L represents the chain of the substructure IX or XIII: -X1-(CH2)m-Q-(CH2)n-X2- IX -X1-(CH2)m-V-(CH2)p-Q-(CH2)n-X2- XIII and Z represents a steroid or nonsteroidal subunit derived from steroid or no...

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Bibliographische Detailangaben
Hauptverfasser:	POLJAK VISNJA, SIJAN GORDANA, SELMANI SELVIRA, MARKOVIC STRIBOR, TOMASKOVIC LINDA, MERCEP MLADEN, MESIC MILAN
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS
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Beschreibung
Zusammenfassung:	Compounds represented by Formula I: wherein M represents a macrolide subunit of the substructure VIII: L represents the chain of the substructure IX or XIII: -X1-(CH2)m-Q-(CH2)n-X2- IX -X1-(CH2)m-V-(CH2)p-Q-(CH2)n-X2- XIII and Z represents a steroid or nonsteroidal subunit derived from steroid or nonsteroidal (NSAID) drugs with anti-inflammatory activity are disclosed. Pharmaceutically acceptable salts and solvates of such compounds, processes and intermediates for their preparation, as well as to the improved therapeutic action and the use in the treatment of inflammatory diseases and conditions in humans and animals are also disclosed.