PREPARATION OF 2S,3S-N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE HYDROCHLORIDE AND OTHER DERIVATIVES OF 2-HYDROXY-1,3-DIAMINES
The present invention provides a new process for the preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in hi...
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| creator | LEACH JOHN ARCHIBALD THOMAS G MIOTKE ROBERT G PALANDOKEN HASAN CARLSON ROLAND P MALIK ASLAM A STRINGER JOY A |
| description | The present invention provides a new process for the preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present invention can be used to prepare not only the 2S,3S-derivative, but also the 2R,3S-, 2S,2R- and the 2R,3R-derivatives. |
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Importantly, the process of the present invention results in higher yields of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present invention can be used to prepare not only the 2S,3S-derivative, but also the 2R,3S-, 2S,2R- and the 2R,3R-derivatives.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20081218&DB=EPODOC&CC=US&NR=2008312469A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20081218&DB=EPODOC&CC=US&NR=2008312469A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LEACH JOHN</creatorcontrib><creatorcontrib>ARCHIBALD THOMAS G</creatorcontrib><creatorcontrib>MIOTKE ROBERT G</creatorcontrib><creatorcontrib>PALANDOKEN HASAN</creatorcontrib><creatorcontrib>CARLSON ROLAND P</creatorcontrib><creatorcontrib>MALIK ASLAM A</creatorcontrib><creatorcontrib>STRINGER JOY A</creatorcontrib><title>PREPARATION OF 2S,3S-N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE HYDROCHLORIDE AND OTHER DERIVATIVES OF 2-HYDROXY-1,3-DIAMINES</title><description>The present invention provides a new process for the preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present invention can be used to prepare not only the 2S,3S-derivative, but also the 2R,3S-, 2S,2R- and the 2R,3R-derivatives.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjUEKwjAQRbtxIeodAm4UOtA2IrpMzZQEaqYkqVg3IhJXokK9jne1FnHtav7w3-cNo1dlsRJWeE2GUcEyF3MHBrSjvPZN2cVZBqqRlvYNcBBbbQgWUCk0Tdkjc6jAaG8pR3NAg64uC-rKDpXI-ulGlWQ_nzCSkVdomUSrd512h673_hxpzEHqjwfdOBpcTtc2TL53FE0L9BsF4XE_hvZxOodbeB5rlyXJiqfZYrkWKf-PegO_qkUT</recordid><startdate>20081218</startdate><enddate>20081218</enddate><creator>LEACH JOHN</creator><creator>ARCHIBALD THOMAS G</creator><creator>MIOTKE ROBERT G</creator><creator>PALANDOKEN HASAN</creator><creator>CARLSON ROLAND P</creator><creator>MALIK ASLAM A</creator><creator>STRINGER JOY A</creator><scope>EVB</scope></search><sort><creationdate>20081218</creationdate><title>PREPARATION OF 2S,3S-N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE HYDROCHLORIDE AND OTHER DERIVATIVES OF 2-HYDROXY-1,3-DIAMINES</title><author>LEACH JOHN ; ARCHIBALD THOMAS G ; MIOTKE ROBERT G ; PALANDOKEN HASAN ; CARLSON ROLAND P ; MALIK ASLAM A ; STRINGER JOY A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2008312469A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2008</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>LEACH JOHN</creatorcontrib><creatorcontrib>ARCHIBALD THOMAS G</creatorcontrib><creatorcontrib>MIOTKE ROBERT G</creatorcontrib><creatorcontrib>PALANDOKEN HASAN</creatorcontrib><creatorcontrib>CARLSON ROLAND P</creatorcontrib><creatorcontrib>MALIK ASLAM A</creatorcontrib><creatorcontrib>STRINGER JOY A</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LEACH JOHN</au><au>ARCHIBALD THOMAS G</au><au>MIOTKE ROBERT G</au><au>PALANDOKEN HASAN</au><au>CARLSON ROLAND P</au><au>MALIK ASLAM A</au><au>STRINGER JOY A</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PREPARATION OF 2S,3S-N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE HYDROCHLORIDE AND OTHER DERIVATIVES OF 2-HYDROXY-1,3-DIAMINES</title><date>2008-12-18</date><risdate>2008</risdate><abstract>The present invention provides a new process for the preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride, wherein this compound is prepared directly from the chloromethylalcohol. Importantly, the process of the present invention results in higher yields of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride without sacrificing its purity. The processes of the present invention can be used to prepare not only the 2S,3S-derivative, but also the 2R,3S-, 2S,2R- and the 2R,3R-derivatives.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY METALLURGY ORGANIC CHEMISTRY |
| title | PREPARATION OF 2S,3S-N-ISOBUTYL-N-(2-HYDROXY-3-AMINO-4-PHENYLBUTYL)-P-NITROBENZENESULFONYLAMIDE HYDROCHLORIDE AND OTHER DERIVATIVES OF 2-HYDROXY-1,3-DIAMINES |
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