Pyrrolyl Substituted Pyrido[2,3-D]Pyrimidin-7-Ones and Derivatives Thereof as Therapeutic Agents
The present invention provides pyrimidines of Formula I: wherein R2, R4, R5, R6, R8 and J have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases, including inflammatory diseases, cardiovascul...
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| creator | BRUENDL MICHELLE MARIE GOODMAN ANNISE PAIGE REICHARD GREGORY ADAM GOGLIOTTI ROCCO DEAN |
| description | The present invention provides pyrimidines of Formula I: wherein R2, R4, R5, R6, R8 and J have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I. |
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Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2008</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20081016&DB=EPODOC&CC=US&NR=2008255162A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25544,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20081016&DB=EPODOC&CC=US&NR=2008255162A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BRUENDL MICHELLE MARIE</creatorcontrib><creatorcontrib>GOODMAN ANNISE PAIGE</creatorcontrib><creatorcontrib>REICHARD GREGORY ADAM</creatorcontrib><creatorcontrib>GOGLIOTTI ROCCO DEAN</creatorcontrib><title>Pyrrolyl Substituted Pyrido[2,3-D]Pyrimidin-7-Ones and Derivatives Thereof as Therapeutic Agents</title><description>The present invention provides pyrimidines of Formula I: wherein R2, R4, R5, R6, R8 and J have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2008</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZEgIqCwqys-pzFEILk0qLsksKS1JTVEACmam5Ecb6RjrusSCOLmZKZl5uua6_nmpxQqJeSkKLqlFmWWJJZllQH5IRmpRan6aQiKEmViQWlqSmazgmJ6aV1LMw8CalphTnMoLpbkZlN1cQ5w9dFML8uNTiwsSk1PzUkviQ4ONDAwsjExNDc2MHA2NiVMFAGDJPYw</recordid><startdate>20081016</startdate><enddate>20081016</enddate><creator>BRUENDL MICHELLE MARIE</creator><creator>GOODMAN ANNISE PAIGE</creator><creator>REICHARD GREGORY ADAM</creator><creator>GOGLIOTTI ROCCO DEAN</creator><scope>EVB</scope></search><sort><creationdate>20081016</creationdate><title>Pyrrolyl Substituted Pyrido[2,3-D]Pyrimidin-7-Ones and Derivatives Thereof as Therapeutic Agents</title><author>BRUENDL MICHELLE MARIE ; GOODMAN ANNISE PAIGE ; REICHARD GREGORY ADAM ; GOGLIOTTI ROCCO DEAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2008255162A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2008</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BRUENDL MICHELLE MARIE</creatorcontrib><creatorcontrib>GOODMAN ANNISE PAIGE</creatorcontrib><creatorcontrib>REICHARD GREGORY ADAM</creatorcontrib><creatorcontrib>GOGLIOTTI ROCCO DEAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BRUENDL MICHELLE MARIE</au><au>GOODMAN ANNISE PAIGE</au><au>REICHARD GREGORY ADAM</au><au>GOGLIOTTI ROCCO DEAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Pyrrolyl Substituted Pyrido[2,3-D]Pyrimidin-7-Ones and Derivatives Thereof as Therapeutic Agents</title><date>2008-10-16</date><risdate>2008</risdate><abstract>The present invention provides pyrimidines of Formula I: wherein R2, R4, R5, R6, R8 and J have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula I.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Pyrrolyl Substituted Pyrido[2,3-D]Pyrimidin-7-Ones and Derivatives Thereof as Therapeutic Agents |
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