Glipizide controlled-release composition and method of preparation
A glipizide controlled release composition is provided comprising a drug-layer and a push-layer at a ratio of 1:0.5~3 by weight. The drug-layer contains glipizide and 40~99 percent by weight of the drug-layer of hydrophilic polyvinylpyrrolidone homopolymer and/or copolymer carrier. The push-layer co...
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| Sprache: | eng |
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| Zusammenfassung: | A glipizide controlled release composition is provided comprising a drug-layer and a push-layer at a ratio of 1:0.5~3 by weight. The drug-layer contains glipizide and 40~99 percent by weight of the drug-layer of hydrophilic polyvinylpyrrolidone homopolymer and/or copolymer carrier. The push-layer comprises about 10 to 80 percent by weight of the push-layer of osmopolymers, about 10 to 80 percent by weight of the push-layer of water-insoluble polymers, and about 5 to 50 percent by weight of the push-layer of osmagents. The composition is used in osmotic pump tablets for controlled release of glipizide useful for administration once a day. |
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