NEUTRALIZING ANTIBODIES AGAINST GDF-8 AND USES THEREFOR

The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in vitro and/or in vivo. The disclosure also provides methods for diagnosing, preventing, or treating dege...

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Bibliographische Detailangaben
Hauptverfasser: VELDMAN GEERTRUIDA M, DAVIES MONIQUE V, RUSSELL CAROLINE, FIELD ANNE, SONG KENING, BRIDGES KRISTIE G, VALGE-ARCHER VIIA, WOLFMAN NEIL M
Format: Patent
Sprache:eng
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Zusammenfassung:The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), in particular human antibodies, and antibody fragments, including those that inhibit GDF-8 activity in vitro and/or in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle or bone, or disorders of insulin metabolism.