2-Anilino-4-(Heterocyclic) Amino-Pyrimidines

2-Anilino-4-(Heterocyclic) Amino-Pyrimidines

The present invention relates to 2-arylamino-4-(heterocyclic)aminopyrimidines inhibitors which are inhibitors and therefore inhibit Protein Kinase C-alpha (PKC-alpha). The PKC-alpha inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in...

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Hauptverfasser: GOLEBIOWSKI ADAM, SHRUM GARY P, HUNTER JACK A, DJUNG JANE F
Format: Patent
Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator GOLEBIOWSKI ADAM
SHRUM GARY P
HUNTER JACK A
DJUNG JANE F
description The present invention relates to 2-arylamino-4-(heterocyclic)aminopyrimidines inhibitors which are inhibitors and therefore inhibit Protein Kinase C-alpha (PKC-alpha). The PKC-alpha inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in improved myocardial contraction and relaxation performance and thereby slowing the progression of heart failure. The present invention further relates to compositions comprising said 2-arylamino-4-(heterocyclic)amino-pyrimidines and to methods for controlling, abating, or otherwise slowing the progression of heart failure.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title 2-Anilino-4-(Heterocyclic) Amino-Pyrimidines
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