Preparation of oxycodone
A process for preparing oxycodone or an oxycodone salt, wherein the oxycodone or oxycodone salt has low levels of impurities (especially 14-hydroxycodeinone) is disclosed. The process comprises the steps of: a) preparing a mixture comprising oxycodone and a solvent and adjusting the pH of the mixtur...
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| creator | CASNER MICHAEL L DUNG JEN-SEN KESKENY ERNO M LUO JIN |
| description | A process for preparing oxycodone or an oxycodone salt, wherein the oxycodone or oxycodone salt has low levels of impurities (especially 14-hydroxycodeinone) is disclosed. The process comprises the steps of: a) preparing a mixture comprising oxycodone and a solvent and adjusting the pH of the mixture to less than 6; and subsequently b) exposing the mixture to hydrogenation reagents for a period of at least 1 hour. This process provides oxycodone with very low levels of alpha,beta-unsaturated ketone impurities. Oxycodone or an oxycodone salt produced according to the process of the invention has low levels of alpha,beta-unsaturated ketones and is advantageously incorporated into pharmaceutical products. |
| format | Patent |
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The process comprises the steps of: a) preparing a mixture comprising oxycodone and a solvent and adjusting the pH of the mixture to less than 6; and subsequently b) exposing the mixture to hydrogenation reagents for a period of at least 1 hour. This process provides oxycodone with very low levels of alpha,beta-unsaturated ketone impurities. 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Oxycodone or an oxycodone salt produced according to the process of the invention has low levels of alpha,beta-unsaturated ketones and is advantageously incorporated into pharmaceutical products.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJAIKEotSCxKLMnMz1PIT1PIr6hMzk_Jz0vlYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXxocFGBgbmRhaGlqYWjobGxKkCAJPyI3k</recordid><startdate>20071206</startdate><enddate>20071206</enddate><creator>CASNER MICHAEL L</creator><creator>DUNG JEN-SEN</creator><creator>KESKENY ERNO M</creator><creator>LUO JIN</creator><scope>EVB</scope></search><sort><creationdate>20071206</creationdate><title>Preparation of oxycodone</title><author>CASNER MICHAEL L ; DUNG JEN-SEN ; KESKENY ERNO M ; LUO JIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2007281958A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2007</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>CASNER MICHAEL L</creatorcontrib><creatorcontrib>DUNG JEN-SEN</creatorcontrib><creatorcontrib>KESKENY ERNO M</creatorcontrib><creatorcontrib>LUO JIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>CASNER MICHAEL L</au><au>DUNG JEN-SEN</au><au>KESKENY ERNO M</au><au>LUO JIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Preparation of oxycodone</title><date>2007-12-06</date><risdate>2007</risdate><abstract>A process for preparing oxycodone or an oxycodone salt, wherein the oxycodone or oxycodone salt has low levels of impurities (especially 14-hydroxycodeinone) is disclosed. 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Preparation of oxycodone |
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