Process for Lactonization in the Preparation of Statins

Process for Lactonization in the Preparation of Statins

The present invention relates to an improved and industrial friendly process for lactonization to produce compound of the Formula [I], from compound of the Formula [II] in presence of an inorganic compound as a suitable lactonizing agent, preferably alkali metal hydrogen sulfate, and crystallizing t...

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Hauptverfasser: KHANNA JAG M, SINGH GOVIND, BHADWAL PARAMVIR, PANCHASARA DINESH R, JAISWAL SANJAY, THAPER RAJESH T, DUBEY SUSHIL K
Format: Patent
Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator KHANNA JAG M
SINGH GOVIND
BHADWAL PARAMVIR
PANCHASARA DINESH R
JAISWAL SANJAY
THAPER RAJESH T
DUBEY SUSHIL K
description The present invention relates to an improved and industrial friendly process for lactonization to produce compound of the Formula [I], from compound of the Formula [II] in presence of an inorganic compound as a suitable lactonizing agent, preferably alkali metal hydrogen sulfate, and crystallizing the obtained lactone product in a solvent; or treating compound of the Formula [II] in the presence of an inorganic compound preferably alkali metal hydrogen sulfate using phase transfer catalyst in heterogeneous phase followed by crystallizing the obtained lactone product in a solvent.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title Process for Lactonization in the Preparation of Statins
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