Nucleic Acid Molecules As Herpanase Potent Inhibitors, Compositions And Methods Of Use Thereof

Disclosed herein are ribonucleic acid molecules, specifically ribozymes and siRNAs, whose sequence is at least partially complementary to heparanase mRNA. Said molecules may thus be used for the specific inhibition of heparanase, and as therapeutics for pathologic conditions associated with heparanase expression, like for example tumor formation, progression and metastasis, tumor-associated angiogenesis, inflammatory disorders, kidney disorders and autoimmune disorders. Vectors, cells and compositions comprising said ribonucleic acid molecules are also disclosed herein.