METHODS OF INCREASING PRODUCTION OF SECONDARY METABOLITES BY MANIPULATING METABOLIC PATHWAYS THAT INCLUDE METHYLMALONYL-COA

METHODS OF INCREASING PRODUCTION OF SECONDARY METABOLITES BY MANIPULATING METABOLIC PATHWAYS THAT INCLUDE METHYLMALONYL-COA

A process of increasing the cellular production of secondary metabolites, such as antibiotics, is provided. The process is particularly useful for increasing antibiotic production by bacterial cells, especially erythromycin. The process includes the step of increasing the activity of methylmalonyl-C...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WEBER J. M, REEVES ANDREW, BRIKUN IGOR A
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:A process of increasing the cellular production of secondary metabolites, such as antibiotics, is provided. The process is particularly useful for increasing antibiotic production by bacterial cells, especially erythromycin. The process includes the step of increasing the activity of methylmalonyl-CoA mutase.