New 3-phenylpropionic acid derivatives
The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or -COO-C1-C4-alkyl group; Y represents NH, N-C1-C10-alkyl, O, or S; Z represents NH, N-C1-C10-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH...
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| creator | MAJKA ZBIGNIEW STAWINSKI TOMASZ KUROWSKI KRZYSZTOF RUSIN KATARZYNA E SAWICKI ANDRZEJ W SULIKOWSKI DANIEL MATUSIEWICZ KATARZYNA J |
| description | The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or -COO-C1-C4-alkyl group; Y represents NH, N-C1-C10-alkyl, O, or S; Z represents NH, N-C1-C10-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N-C1-C10-alkyl, N-aryl, NSO2-C1-C10-alkyl, N-SO2-aryl, or N-SO2-heteroaryl; R1 to R8 each independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments. |
| format | Patent |
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The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2007</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070419&DB=EPODOC&CC=US&NR=2007088061A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070419&DB=EPODOC&CC=US&NR=2007088061A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MAJKA ZBIGNIEW</creatorcontrib><creatorcontrib>STAWINSKI TOMASZ</creatorcontrib><creatorcontrib>KUROWSKI KRZYSZTOF</creatorcontrib><creatorcontrib>RUSIN KATARZYNA E</creatorcontrib><creatorcontrib>SAWICKI ANDRZEJ W</creatorcontrib><creatorcontrib>SULIKOWSKI DANIEL</creatorcontrib><creatorcontrib>MATUSIEWICZ KATARZYNA J</creatorcontrib><title>New 3-phenylpropionic acid derivatives</title><description>The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or -COO-C1-C4-alkyl group; Y represents NH, N-C1-C10-alkyl, O, or S; Z represents NH, N-C1-C10-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N-C1-C10-alkyl, N-aryl, NSO2-C1-C10-alkyl, N-SO2-aryl, or N-SO2-heteroaryl; R1 to R8 each independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2007</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFDzSy1XMNYtyEjNq8wpKMovyMzPy0xWSEzOTFFISS3KLEssySxLLeZhYE1LzClO5YXS3AzKbq4hzh66qQX58anFBYnJqXmpJfGhwUYGBuYGFhYGZoaOhsbEqQIACi8ohQ</recordid><startdate>20070419</startdate><enddate>20070419</enddate><creator>MAJKA ZBIGNIEW</creator><creator>STAWINSKI TOMASZ</creator><creator>KUROWSKI KRZYSZTOF</creator><creator>RUSIN KATARZYNA E</creator><creator>SAWICKI ANDRZEJ W</creator><creator>SULIKOWSKI DANIEL</creator><creator>MATUSIEWICZ KATARZYNA J</creator><scope>EVB</scope></search><sort><creationdate>20070419</creationdate><title>New 3-phenylpropionic acid derivatives</title><author>MAJKA ZBIGNIEW ; STAWINSKI TOMASZ ; KUROWSKI KRZYSZTOF ; RUSIN KATARZYNA E ; SAWICKI ANDRZEJ W ; SULIKOWSKI DANIEL ; MATUSIEWICZ KATARZYNA J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_US2007088061A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2007</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>MAJKA ZBIGNIEW</creatorcontrib><creatorcontrib>STAWINSKI TOMASZ</creatorcontrib><creatorcontrib>KUROWSKI KRZYSZTOF</creatorcontrib><creatorcontrib>RUSIN KATARZYNA E</creatorcontrib><creatorcontrib>SAWICKI ANDRZEJ W</creatorcontrib><creatorcontrib>SULIKOWSKI DANIEL</creatorcontrib><creatorcontrib>MATUSIEWICZ KATARZYNA J</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MAJKA ZBIGNIEW</au><au>STAWINSKI TOMASZ</au><au>KUROWSKI KRZYSZTOF</au><au>RUSIN KATARZYNA E</au><au>SAWICKI ANDRZEJ W</au><au>SULIKOWSKI DANIEL</au><au>MATUSIEWICZ KATARZYNA J</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>New 3-phenylpropionic acid derivatives</title><date>2007-04-19</date><risdate>2007</risdate><abstract>The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or -COO-C1-C4-alkyl group; Y represents NH, N-C1-C10-alkyl, O, or S; Z represents NH, N-C1-C10-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N-C1-C10-alkyl, N-aryl, NSO2-C1-C10-alkyl, N-SO2-aryl, or N-SO2-heteroaryl; R1 to R8 each independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | New 3-phenylpropionic acid derivatives |
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