Inhibition of cell motility, angiogenesis, and metastasis

Inhibition of cell motility, angiogenesis, and metastasis

Disclosed are methods of inhibiting cell motility, for example, by inhibiting the binding between an intracellular transducer and a receptor protein tyrosine kinase, and more particularly by inhibiting hepatocyte growth factor (HGF) induced cell motility. The present invention also provides a method...

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Hauptverfasser: BURKE TERRENCE R.JR, ATABEY SAFIYE N, GIUBELLINO ALESSIO, BOTTARO DONALD P, SORIANO JESUS V, BRECKENRIDGE DIANE E
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator BURKE TERRENCE R.JR
ATABEY SAFIYE N
GIUBELLINO ALESSIO
BOTTARO DONALD P
SORIANO JESUS V
BRECKENRIDGE DIANE E
description Disclosed are methods of inhibiting cell motility, for example, by inhibiting the binding between an intracellular transducer and a receptor protein tyrosine kinase, and more particularly by inhibiting hepatocyte growth factor (HGF) induced cell motility. The present invention also provides a method of inhibiting angiogenesis. The methods of the present invention employ peptides such as phosphotyrosyl mimetics. Also disclosed are methods of preventing and/or treating diseases, disorders, states, or conditions such as cancer, particularly metastatic cancer, for example, melanoma or prostate cancer, comprising administering to a mammal of interest one or more peptides of the present invention. Also disclosed are methods of blocking blocks HGF, VEGF, or bFGF-stimulated migration, cell proliferation, and formation of capillary-like structures.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Inhibition of cell motility, angiogenesis, and metastasis
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