Process for the preparation of (E)-2-cyano-3-(3, 4-dihydroxy-5-nitrophenyl)-N, N-diethyl-2-propenamide (entacapone)

The present invention relates to an improved process for the preparation of (E)-N,N-diethyl-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide formula (I) comprising steps of, (a) condensation of 3,4-dihydroxy-5-nitrobenzaldehyde of formula (II) with N,N-diethylcyanoacetamide of formula (III) in the...

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Bibliographische Detailangaben
Hauptverfasser: DHAMELIYA DHARMESH R, LUTHRA PARVEN K, PANDEY ANAND K, DESHPANDE PANDURANG B
Format: Patent
Sprache:eng
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