4-aminopyrimidine-5-one derivatives

Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts ha...

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Hauptverfasser:	MULLIN JOHN G.JR, LOVEY ALLEN J, DING QINGJIE, JIANG NAN, VU BINH T, WOVKULICH PETER M, CHU XIN J, BARTKOVITZ DAVID J, MOLITERNI JOHN A
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Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator	MULLIN JOHN G.JR LOVEY ALLEN J DING QINGJIE JIANG NAN VU BINH T WOVKULICH PETER M CHU XIN J BARTKOVITZ DAVID J MOLITERNI JOHN A
description	Novel intermediate compounds are disclosed. These compounds are useful in the synthesis of 4-aminopyrimidine-5-one derivatives that inhibit cyclin-dependent kinases, in particular cyclin-dependent kinase 4 (Cdk4). The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.
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The 4-aminopyrimidine-5-one derivatives and their pharmaceutically acceptable salts have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2006</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20061012&DB=EPODOC&CC=US&NR=2006229330A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20061012&DB=EPODOC&CC=US&NR=2006229330A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MULLIN JOHN G.JR</creatorcontrib><creatorcontrib>LOVEY ALLEN J</creatorcontrib><creatorcontrib>DING QINGJIE</creatorcontrib><creatorcontrib>JIANG NAN</creatorcontrib><creatorcontrib>VU BINH T</creatorcontrib><creatorcontrib>WOVKULICH PETER M</creatorcontrib><creatorcontrib>CHU XIN J</creatorcontrib><creatorcontrib>BARTKOVITZ DAVID J</creatorcontrib><creatorcontrib>MOLITERNI JOHN A</creatorcontrib><title>4-aminopyrimidine-5-one derivatives</title><description>Novel intermediate compounds are disclosed. 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title	4-aminopyrimidine-5-one derivatives
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