System and method for providing exception handling instructions to a delivery agent

A method includes detecting an event which occurs during transportation of a mailpiece on the way from a sender to an addressee. The method further includes determining instructions provided by the sender regarding at least one action to be taken upon occurrence of the event. The instructions are then carried out. In some circumstances, the event may be a delay in delivery of the mailpiece due to contamination or quarantining, and the sender's instructions may specify a manner in which the contents of the mailpiece may be forwarded to the addressee while the mailpiece remains quarantined.