Process for the preparation of 9, 11 epoxy steroids

Process for the preparation of 9, 11 epoxy steroids

Processes are described for epoxidation reactions. In particular, the process comprises the conversion of a steroid substrate having an olefinic unsaturation in the steroid nucleus to a structure comprising a 9,11-epoxy substituent by reaction of the substrate with a peroxide compound in the presenc...

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Hauptverfasser: CARLOS MARLON V, MAISTO KEITH D, WIECZOREK JOSEPH J, KIM CHUNG C, DAVID PAUL
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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creator CARLOS MARLON V
MAISTO KEITH D
WIECZOREK JOSEPH J
KIM CHUNG C
DAVID PAUL
description Processes are described for epoxidation reactions. In particular, the process comprises the conversion of a steroid substrate having an olefinic unsaturation in the steroid nucleus to a structure comprising a 9,11-epoxy substituent by reaction of the substrate with a peroxide compound in the presence of a peroxide activator. The epoxidation processes described are conducted at relatively low hydrogen peroxide to steroid substrate ratio. Several optional process modifications are described.
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subjects CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
title Process for the preparation of 9, 11 epoxy steroids
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