Medical device with porous surface containing bioerodable bioactive composites and related methods

An implantable medical device includes a porous surface with a composite material located within the pores that includes a bioerodable material in combination with a bioactive agent. The composite material is adapted to erode upon exposure to the body of a patient, thus releasing the bioactive agent...

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1. Verfasser: PEACOCK JAMES C.III
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creator PEACOCK JAMES C.III
description An implantable medical device includes a porous surface with a composite material located within the pores that includes a bioerodable material in combination with a bioactive agent. The composite material is adapted to erode upon exposure to the body of a patient, thus releasing the bioactive agent into the patient, whereas the porous surface remains on the device. In one embodiment, the composite material includes micro- or nano-particles that are deposited within the pores. In a further embodiment, the porous surface is an electrolessly electrochemically deposited material. Certain tie layer and other surface modification aspects are described to enhance various aspects of the bioactive composite surface. The bioactive composite surface is of particular benefit when provided on an endolumenal stent assembly in a manner adapted to elute anti-restenosis or anti-thrombosis agents or combinations thereof.
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The composite material is adapted to erode upon exposure to the body of a patient, thus releasing the bioactive agent into the patient, whereas the porous surface remains on the device. In one embodiment, the composite material includes micro- or nano-particles that are deposited within the pores. In a further embodiment, the porous surface is an electrolessly electrochemically deposited material. Certain tie layer and other surface modification aspects are described to enhance various aspects of the bioactive composite surface. 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subjects BANDAGES, DRESSINGS OR ABSORBENT PADS
CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES
DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS
DISINFECTION, STERILISATION, OR DEODORISATION OF AIR
FILTERS IMPLANTABLE INTO BLOOD VESSELS
FIRST-AID KITS
FOMENTATION
HUMAN NECESSITIES
HYGIENE
MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES
MEDICAL OR VETERINARY SCIENCE
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL
ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES
PROSTHESES
TREATMENT OR PROTECTION OF EYES OR EARS
title Medical device with porous surface containing bioerodable bioactive composites and related methods
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