RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic a...
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| creator | WANG WEIMEN USMAN NASSIM HAEBERLI PETER VAISH NARENDRA FOSNAUGH KATHY VARGEESE CHANDRA CHEN TONQIAN CHOWRIRA BHARAT ZINNEN SHAWN MACEJAK DENNIS THOMPSON JAMES BEIGELMAN LEONID MORISSEY DAVID JAMISON SHARON MCSWIGGEN JAMES PAVCO PAMELA |
| description | The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism. |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
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