Pyrazole compounds as integrin receptor antagonists derivatives
The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the alphaVbeta3 and/or the alphaVbeta5 integrin w...
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| creator | CHEN BARBARA B PENNING THOMAS D GANDHI PREETE RUSSELL MARK HUFF RENEE M DOWNS VICTORIA L KHILEVICH ALBERT SPANGLER DALE P WANG YAPING BOYS MARK L |
| description | The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the alphaVbeta3 and/or the alphaVbeta5 integrin without significantly inhibiting the alphaVbeta6 integrin. |
| format | Patent |
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DOWNS VICTORIA L ; KHILEVICH ALBERT ; SPANGLER DALE P ; WANG YAPING ; BOYS MARK L</creatorcontrib><description>The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the alphaVbeta3 and/or the alphaVbeta5 integrin without significantly inhibiting the alphaVbeta6 integrin.</description><edition>7</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050106&DB=EPODOC&CC=US&NR=2005004200A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20050106&DB=EPODOC&CC=US&NR=2005004200A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>CHEN BARBARA B</creatorcontrib><creatorcontrib>PENNING THOMAS D</creatorcontrib><creatorcontrib>GANDHI PREETE</creatorcontrib><creatorcontrib>RUSSELL MARK</creatorcontrib><creatorcontrib>HUFF RENEE M</creatorcontrib><creatorcontrib>DOWNS VICTORIA L</creatorcontrib><creatorcontrib>KHILEVICH ALBERT</creatorcontrib><creatorcontrib>SPANGLER DALE P</creatorcontrib><creatorcontrib>WANG YAPING</creatorcontrib><creatorcontrib>BOYS MARK L</creatorcontrib><title>Pyrazole compounds as integrin receptor antagonists derivatives</title><description>The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the alphaVbeta3 and/or the alphaVbeta5 integrin without significantly inhibiting the alphaVbeta6 integrin.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAPqCxKrMrPSVVIzs8tyC_NSylWSCxWyMwrSU0vysxTKEpNTi0oyS9SSMwrSUzPz8ssLilWSEktyixLLMksSy3mYWBNS8wpTuWF0twMym6uIc4euqkF-fGpxQWJyal5qSXxocFGBgamBgYmQMrR0Jg4VQDRYzLL</recordid><startdate>20050106</startdate><enddate>20050106</enddate><creator>CHEN BARBARA B</creator><creator>PENNING THOMAS D</creator><creator>GANDHI PREETE</creator><creator>RUSSELL MARK</creator><creator>HUFF RENEE M</creator><creator>DOWNS VICTORIA L</creator><creator>KHILEVICH ALBERT</creator><creator>SPANGLER DALE P</creator><creator>WANG YAPING</creator><creator>BOYS MARK L</creator><scope>EVB</scope></search><sort><creationdate>20050106</creationdate><title>Pyrazole compounds as integrin receptor antagonists derivatives</title><author>CHEN BARBARA B ; 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Pyrazole compounds as integrin receptor antagonists derivatives |
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