Synthesis of acyclic nucleoside derivatives

Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a -C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acc...

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Hauptverfasser:	ZHANG WEIJIANG, SINGAM PULLA REDDY, BHAGAVATULA LAKSHMI, SPITZ TIFFANY, PATEL RAMESH R, GATES BRADLEY D, SHELAT BHADRA, MORTON HOWARD, CURTY CYNTHIA B, BELLETTINI JOHN, TIEN JIEN-HEH J, LUKIN KIRILL A, YANG CHENG-XI, LANNOYE GREG, PLATA DANIEL, NARAYANAN BIKSHANDARKOIL A, LEANNA M. ROBERT, TIAN ZHENPING, RILEY DAVID A, KOLACZKOWSKI LAWRENCE, RASMUSSEN MICHAEL, HANNICK STEVEN M, WAYNE GREG, CHANG SOU-JEN
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS APPARATUS THEREFOR CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Methods and novel intermediates for the preparation of acyclic nucleoside derivatives of the formula: where one of R1 and R2 is an amino acid acyl group and the other of R1 and R2 is a -C(O)C3-C21 saturated or monounsaturated, optionally substituted alkyl and R3 is OH or H; or a pharmaceutically acceptable salt thereof.