Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith

Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith

Pharmaceutical compositions that include a drug and/or drug-oligomer conjugate, a fatty acid component and a bile salt component, or a bile salt component without a fatty acid component are described. The drug can be covalently coupled to an oligomeric moiety. The fatty acid component and the bile s...

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Hauptverfasser: OPAWALE FOYEKE, REHLAENDER BRUCE, BOVET LI LI, SOLTERO RICHARD, HICKEY ANTHONY, EKWURIBE NNOCHIRI N
Format: Patent
Sprache:eng
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator OPAWALE FOYEKE
REHLAENDER BRUCE
BOVET LI LI
SOLTERO RICHARD
HICKEY ANTHONY
EKWURIBE NNOCHIRI N
description Pharmaceutical compositions that include a drug and/or drug-oligomer conjugate, a fatty acid component and a bile salt component, or a bile salt component without a fatty acid component are described. The drug can be covalently coupled to an oligomeric moiety. The fatty acid component and the bile salt component, when together, can be present in a weight-to-weight ratio of between 1:15 and 15:1 or any value between. Methods of treating diseases in a subject in need of such treatment using the pharmaceutical compositions of this invention are also provided, as well as methods of providing such pharmaceutical compositions.
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
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